Yale University researchers recently published findings on how a dietary intervention may help prevent the development of systemic lupus erythematosus (SLE). The researchers utilized mouse models of Lupus to test the role of diet and microbiota as well as dissect its mechanisms as the role of commensal bacteria in autoimmunity remains uncertain. It is known that wealthy economies produce certain lifestyle and diet trends and patterns. These “lifestyle” attributes can lead to inflammatory conditions including autoimmune disorder—driven by changes in eating patterns as well as gut microbial composition—included in the study under the “hygiene hypothesis.” Gut microbiota and associated metabolites mediate mucosal and systemic immune responses; changes in composition can be associated with immune disorders.
Lead Research/InvestigatorSource: Cell