Well-Respected Australian Researcher: Consider Triple Therapy (Ivermectin, Zinc, Doxycycline) for COVID-19

Aug 4, 2020 | Australia, COVID-19, Ivermectin, News, Popular Posts, SARS-CoV-2, Thomas Borody

Well-Respected Australian Researcher Consider Triple Therapy (Ivermectin, Zinc, Doxycycline) for COVID-19

Thomas Borody MB,BS, BSc (Med), MD PhD, DSc, FRACP, FACP, FACG, AGAF, touts FDA and TGA approved Ivermectin, which he reports to use regularly in his hospital as it evidences positive results for COVID-19 and should be used immediately to fight the pandemic. The developer of the world’s first cure for peptic ulcers, which saved millions of lives worldwide, employed the same methodology to come up with the Ivermectin triple therapy. With over 30 formal clinical trials, many dozens of observational real-world initiatives and hundreds to possibly thousands of doctors already using the medicine, a particular momentum gains speed for additional randomized controlled trials and, just as importantly, a more serious dialogue about the potential of this approach for pragmatic and economical treatment options for COVID-19.

The Real World Evidence

TrialSite has been tracking the use of Ivermectin since researchers at Australia’s Monash University and Peter Doherty Institute found that in the lab’s cell culture the anti-parasitic absolutely destroyed the pathogenTrialSite found and interviewed doctors from Bangladesh and India to the Dominican Republic, Peru, Columbia and Iraq to the United States where Broward County Health approved an Ivermectin-based protocol with successful outcomes.  A French company called Medincell even announced it would work on commercializing an ivermectin-based COVID-19 therapy. Search TrialSite for what are now many dozens of relevant real world data points. 

TrialSite acknowledges the not only the importance of, but the necessity of randomized controlled studies; hence why the continuous reporting of important studies, such as University of KentuckySheba Medical CenterKKR-backed Max Healthcare, Bangladesh Medical College and many other centers around the world.

Additionally, TrialSite is contributing to a significant clinical trial in the works in the United States. Targeting up to 2,000 patients, several hospitals seek to participate. The drug manufacturer will donate the drug and the high profile clinical trial operations experts have been engaged.

TrialSite Cautionary Point

Of course, TrialSite reminds all that despite the potential, this treatment is not approved in the United States nor in most nations, and per the U.S. Food and Drug Administration (FDA) any such health therapy that is associated with a claim must go through formally designed and approved clinical trials unless its use can fit into an acceptable off-label scenario.  

Moreover, there is no cure for COVID-19. The only two drugs that are accepted by the FDA at this point are Remdesivir (via emergency use) and Dexamethasone (as it was included in the NIH’s clinical guidelines). The government also has accepted an emergency use protocol for convalescent plasma led by Mayo Clinic.  

Of course, the hope is that a combination of safe and effective vaccines combined with advanced therapies in development, such as promising investigational antibodies including  REGN-COV2, may help finally beat this pathogen.

Moreover, investigational antivirals or anti-parasitic are not cures either. If found to be safe and effective, they are used as part of a comprehensive COVID-19 management to treat at onset in a bid to reduce the severity of the infection which will hopefully help lessen the strain on the health care system as well as reduce the severity and the duration of the condition which can help society in a number of important ways. Effectively taking on and beating COVID-19 (and any future deadly pathogens) takes a combined and flexible approach based on evidence (from trials and real world).

The Australian Triple Therapy

Although Dr. Borody calls it an “Australian Triple Therapy,” a similar approach is used from Bangladesh and India to South America. Dr. Borody reports the combination of three approved “off the shelf” drugs may point to an answer of Australia’s COVID-19 crisis.

Professor Borody reports:

·         “If nothing else, make it available in aged care homes immediately. Our elderly is at the highest risk and this is a very safe option especially when we have nothing else except ventilators.”

·         “Also, our frontline workers deserve more protection with a preventative medication like this, and as emergency treatment if they test positive.”

·         “An Ivermectin tablet can cost as little as $2 – which could make it by far the cheapest, safest, and fastest cure for Australians and the Australian economy.”

Borody on Safety

The Professor reports that Ivermectin has a good safety profile and, in fact, WHO reports, ‘Mass treatment with ivermectin: an underutilized public health strategy’…”Its time to capitalize on the full public health potential of ivermectin” as an anti-parasitic

Furthermore in the recent Australian-originated press release: in the Journal of Antibiotics, a 12 June 2020 report on Ivermectin says

“Several studies reported antiviral effects of ivermectin on RNA viruses such as Zika, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, and severe acute respiratory syndrome coronavirus 2.”

Ivermectin Therapy for COVID-19

Professor Borody points to his research that led him to a triple therapy of Ivermectin, zinc and an antibiotic—which are all TGA and FDA approved—which could be the fastest and safest way to stop the Victorian outbreak within 6-8 weeks. For more on this see Professor Borody’s published research papers, see here

Professor Borody commented, “When State and Federal governments are saying they will do whatever it takes then I believe this is a potential life-saver right now.” He continued, “These medications are already approved. They do not need pre-clinical or clinical trials nor additional TGA approvals unless the aim is to combine in a single capsule, for example. Patient treatment programs have been done in the US and elsewhere which indicate it can work in 4-6 days.”

The professor argues in a recent press release that he has extensively reviewed the key antiviral scientific research literature and identified the combination of three drugs that are in chemists right now and can be prescribed by doctors immediately. Borody believes that the tablets can be taken at home as preventive treatment by high-risk individuals, or by those who test positive to minimize need for hospitalization at the higher curative dose.

What is this triple therapy?

  1. Ivermectin—TGA and FDA approved as an anti-parasitic therapy with an established safety profile since the 1970s. Known as a “Wonder Drug”  from Japan
  2. Zinc
  3. Doxycycline—TGA and FDA approved tetracycline antibiotic fights infections such as acne, urinary tract infections, etc.

Lead Research/Investigator

Thomas Borody, MB,BS, BSc (Med), MD PhD, DSc, FRACP, FACP, FACG, AGAF

Call to ActionTrialSite, an independent online media platform focused on clinical research accessibility and transparency with an emphasis on the research site, continues to accumulate significant data associated with Ivermectin and COVID-19 worldwide. Shortly, a TrialSite produced documentary on the topic in South America will be released to the public. Interested in connecting? Contact TrialSIte News.

Source: medianet.

66 Comments

  1. ML

    Excellent news, indeed! Thank you so much, TSN!

    • Sabdar Rahaman

      Really great advice. At Kolkata Asprin with AV is also added.

    • Yakubu O. H

      We use Ivermectin, azithromycin, zinc and vitamin c in my center with 100% cure rate. In serious cases, ceftriaxone is added with other supportive measures.

    • Bill Reynolds

      Have any patients Died while on a course of ivomectin that were put on the drug before they became critically ill?

  2. Charat Sharma

    I truly appreciate this nd i am a witness yo this therapy, suggested this combination to 40 if my close relatives in hyderabad. One of person had breathing issues nd lung infection, all recovered in 5 days, its a WONDER DRUG.

    • Srikanth

      Dosage please?

      • Gerald Horn MD

        Use with Plaquenil (nl ekg) vs Doxy?*

        * Broward County

      • F carter

        Yes please what is the dosage ???

        • howard m may

          Please let us know the dosing for treatment

    • bharat

      kindly guide as have covid patients at home 9511555557

      • Muhammad MasudWww

        In Bangladesh, this therapy is giving good result s ,even for patients with mild to moderate infection and being cured at home.

    • Srikanth

      Please let me know the dosage of Ivermectin and Doxycycline for Mild to Moderate Covid. My email address is jyotikanaru@yahoo.com

      • Cynthia Lundie

        Doxycycline 200mg 2x day for 7 days; Zinc 75-100 mg daily preferably as lozenge with Zinc Gluconate for 7 days; Ivermectin one time dose by body weight 150 mcg per Kilogram or 68 mcg per pound. Helpful to add following vitamins/ supplements: 1000 mg vitamin C; 2000 – 4000 mg Vitamin D; 500 mg Quercetin, 3mg Melatonin (at night); 100 mg Magnesium

        • Santosh Tiwari

          Please elaborate in clear way what should be dose for kids and adults

        • shridhar chame

          Agree with above but higher dose ivermictin 600mcg/kg is recommended for covid 19

          • Mary Forbus

            Why such a larger dose

      • Ram Bahadur

        u.p . government have given permission for use ivermectine to treat covid19 patients.

    • Markos fahmy

      What are the doses for each drug ?and duration?

    • Gino Boselli

      Il problema grande di questi farmaci è che costano molto poco e solo pochi medici molto onesti. non avidi di denaro e responsabili dei costi dei servizi nazionali li prescrivono. Sono dei benemeriti perché pensano solo agli interessi dei loro pazienti e dello stato rifuggendo dagli enormi interessi che ha Big Parma che propone il remdesivir al costo di soli 300 euro a dose che ha fallito tutte le sperimentazioni contro altri virus. Col costo di um solo ciclo di remdesivir si possono curare e forse MEGLIO, centinaia di persone con benefici anche degli stati. Pertanto è altamente possibile, vista l enorme disparità di costi che chi prescrive remdesivir sia a libro paga di big pharma e quindi a tutti gli effetti un miserevole corrotto che pensa in primis al bene del suo portafoglio. Ignobile e da esecrare.

  3. Judy Wilson

    Surely all the health fraternity should be hopping into this with both hands. It is worthy of trial. I personally would have no hesitation in using this treatment. Good on Professor Borody in offering this treatment. His continued work is so vital and I thank him for his ongoing studies. For goodness take what is being offered and use this treatment. I am familiar with all three drugs and I can’t for the life of me understand why the Government Health authority have dismissed this treatment. God bless the good Professor in his work to save lives. Judy Wilson Wyreeme Qld.

    • Lidia

      I would have to agree. Prof Borody is my mother’s gastroenterologist for the last 30+ years a highly respected specialist and researcher. He has an amazing clinic at Five Dock in NSW Australia. He is someone I trust completely. If he says it’s a potential cure anf worth a try especially as it has been used with great success overseas I would definately listen to him. God bless him and all the great work he does.

  4. Srikanth

    Dosage of Ivermectin & Doxycycline please. My email jyotikanaru@yahoo.com

    • Mohamed Fouad

      Dosage of Ivermectin & Doxycycline please.
      My email Dr. Mfaa@gmail.com

      • Cynthia Lundie

        Doxycycline 200mg 2x day for 7 days; Zinc 75-100 mg daily preferably as lozenge with Zinc Gluconate for 7 days; Ivermectin one time dose by body weight 150 mcg per Kilogram or 68 mcg per pound. Helpful to add following vitamins/ supplements: 1000 mg vitamin C; 2000 – 4000 mg Vitamin D; 500 mg Quercetin, 3mg Melatonin (at night); 100 mg Magnesium

        • Bernadette Taylor

          There is no talk of the Ivermectin triple therapy where we are in southern NSW if people are infected. .
          I am concerned doctors will not prescribe for at risk people.
          Ivermectin is not readily available but closely related compounds used orally in sheep are freely available.
          Would you comment please.
          My husband and l are ederly and both are high risk.

          • Nonod

            https://www.researchgate.net/publication/342170742_Ivermectin_for_Covid-19

            About the concerns of using a drug involved in veterinary use, an answer was the following.

            We can find Ivermectin in the formulation for human and veterinary use. The formulations for
            human use are in short supply and at a very high cost. So, a question is “Can we use veterinary
            medicine?” Elera’s answer is the following: “Sure. It is not toxic. We have used the formulation for
            veterinary use for the … The difference (in the formulation) of Ivermectin for human use and for
            veterinary use is the following. The formulation for human use is Ivermectin plus water and
            Sorbitol, which is a flavouring that makes it sweet. The formulation for veterinary use is Ivermectin
            plus water, plain and simple. Elera’ answer is translated because, in a following sections, the two
            formulations of ivermectin will be discussed in detail.

            the first line of defense against
            this drug, at least in the developed “first world,” was that Ivermectin was an “animal drug.” This
            sort of bias was evidenced clearly by the FDA’s Ivermectin warning. Titled “FAQ : COVID-19 and
            Ivermectin Intended for Animals,” the FDA took overt advantage of a loaded headline to convey an
            underlying point. … But did they think anyone would take them seriously? But it was Created for
            Humans. In reality, Ivermectin was in fact created for humans. In Peru, doctors are treating
            COVID-19 patients with one drop every 24 hours for two days and many physicians report within a
            month they see patients fully recovered”.

          • TrialSite

            Hello Nonod,
            Yes we caught the FDA comments and agree with your point. It seemed like they titled the communication for a specific effect. Now if you read on they become quite open stating that in so many words they encourage Ivermectin clinical trials to produce evidence. But clearly the opening was loaded….
            Thanks for visiting TrialSite!
            Publisher

    • Avneesh Tomar

      20 MG for a person of 60KG weight. My sister in Delhi was given this dose by Max Hospital.

    • Azuka Onyiaorah

      Please send me dosage for Ivermectin, Zinc and dosycycline

    • Cynthia Lundie

      Doxycycline 200mg 2x day for 7 days; Zinc 75-100 mg daily preferably as lozenge with Zinc Gluconate for 7 days; Ivermectin one time dose by body weight 150 mcg per Kilogram or 68 mcg per pound. Helpful to add following vitamins/ supplements: 1000 mg vitamin C; 2000 – 4000 mg Vitamin D; 500 mg Quercetin, 3mg Melatonin (at night); 100 mg Magnesium

  5. Anthony

    Gonna be thought to find anything to work here in the USA this is a political nightmare and really illegal all these politicians should be held accountable for half the deaths they caused in the United States of America not treating us people with improved medications !Just to take down OneMan great work Australia!

  6. DR. TANISH MODI

    I HAD USE THIS TRIPPLE COMBINATION INY MORE THAN 50 PT , IT WILL SHOW PROMISING REZULT AND CAUSE COVID 19 NEGATIVE WITH LESS CYTOCHROME STROM AND VIRULENCE. SMOOTH COURSE OF DISEASES WITH LITTLE COMPLICATION . I ALSO ADDED ORAL METHYL PREDNISOLONE TO MY PERSISTANT FEVER PT AND GGO ON HRCT THORAX

    • Ajay Malshe

      What strength like 6 mg , 12 mg n doses of ivermectin n antibiotic? Pl inform.

      • Avneesh Tomar

        20 MG for a person of 60KG weight. My sister in Delhi was given this dose by Max Hospital.

    • bharat

      Kindly help have 3 covid patients at home in pune 9511555557

    • Santosh Kumar Tiwari

      Please elaborate in clear way what should be dose for kids and adults

  7. RANAJIT BANDYOPADHYAY

    Is there a guideline on the dosages of Ivermectin, zinc and the antibiotic

    • ML

      A Mexican doctor gave my Covid positive friend 12 mg of Ivermectin for two days in a row. And also he prescribed Azithromycin in the usual 5 day course. As for zinc, I’d imagine one would take around 75 to 100 mg of zinc for that week. Don’t take this much zinc routinely though, as it will interfere with copper absorption. If you decide to use Doxycycline instead of the Azithromycin, the usual dose for Doxy is 100 mg bid for the week to ten days. The Mexican doc also told my friend to take a baby aspirin or one regular aspirin each day for a week, if she did not have allergies or contraindications, to any of the above of course. She was well in FIVE days. Her fever went away in TWO days. I know this is anecdotal, but people are dying. We need help and the USA is allowing people to sicken and die in the meantime. Thank heavens for the Mexican doctor who helped her. She is 63 years old, in a higher risk group.

  8. Sheila

    The most maddening part of this crisis is not the disease. It’s the way the powers that be are handling it. They’re unrealistic to think that people are going to want to wait 12-18 months in a bid to save lives yet here are drugs that help save lives and they ignore it! What is going on behind the scenes that is causing these massive delays that end up killing more people in the meantime? Enough is enough! We do not need clinical trials for zinc! You can get zinc at the dollar store! The people of the US should be allowed these options instead of just overpriced Remdesivir!

  9. Purushottam Agrawal

    We will be thankful if advised its dosage for adults and children, so we can take in case of emergency

    • Mohamed

      I think the cotrimoxazole,dexamethasone,ascorbic acid is better for Corona virus

  10. Ram Bahadur

    experiment experiment more and more experiment but when it will be available for all?

  11. Randolph W Lievertz, MD / Clinical NeuroPsychoPharmacology

    As this is technically experimental I can only relay what is currently experimental:

    The working dosage of Ivermectin based upon animal studies and human laboratory cell cultures is 1 mg/kg body weight orally once daily for 3 consecutive days. This is higher than the antiparasitic dose but within the dosing range for anti-viral dosing. The main adverse effects may be lower extremity weakness and visual impairment. Both effects are completely reversible within 3 to 10 days after the course of Ivermectin is completed.

    Doxycycline 100 mg twice daily for seven to ten days mainly prevents secondary bacterial, mycoplasma, and chlamydia (pulmonary) infection. Use with descretion. Definitely use for smokers, COPD, and asthma patients.

    Prevention of pulmonary, cardiac, and renal fibrosis with Dipyridamole 50 mg orally 3 times (1 every 6 – 8 hours) daily for fourteen (14) days has been documented in American trials to be effective.

    High potency corticosteroids (dexamethasone) are only of benefit after pulmonary fibrosis has occurred or the patient is a candidate for placement on a ventilator. They have not been shown to be of benefit in non-ventilator patients.

    The Covid-19 virus enters cells through the ACE2 receptor. Theoretically an ACE inhibitor could block the ACE2 receptors resulting in slowing of spread of infection through the body. The effectiveness would be dependent on the number of ACE inhibitor molecules in the body compared to the number of viral particles in the body. Competitive inhibitors of the ACE receptors would be less effective than non-competitive inhibitors. The actual clinical value of using ACE inhibitors has yet to be determined.

    Remdesivir is administered intravenously. Oral famciclovir may block, inhibit, slow, or prevent infection. It may lead to a mild or symptomless infection. Remdesivir is metabolised to a nucleic acid blocker as is famciclovir. These two drugs work to inhibit two different RNA nucleic acid bindings so may work equally well. These 2 drugs might be more effective when given simultaneously. This needs to be evaluated in animal & human cell culture to see if they are equally effective. Unlike most nucleic acid binding substitutes, once famciclovir becomes tri-phosphorilated it remains intracellular while other similar drugs are still free to cross out of the cell when tri-phosphorilated. This gives famciclovir a longer intracellular half life and may explain it’s broader anti-viral properties. Speculatively famciclovir’s oral dosage would be 500 mg twice daily.

    I hope I have given you food for thought and possibly suggested new avenues of research in our battle against the Covid-19 virus.

  12. Kazi

    Doses please.
    Can these drugs be used as preventives?

    • ML

      Watch the Dr. Stricker interview on the podcast on this site, TSN. It was posted a while back. He mentioned that hydroxychloroquine was probably best used as a prophylactic against Covid by taking a 400 mg in a ONCE A WEEK DOSE to prevent infection. I don’t know if Ivermectin weekly would prevent infection, but Dr. Stricker definitely thinks HCQ taken once a week, would prevent infection. He says that is the best use for it. Sounds like Ivermectin is best used after infection, the earlier the better, but may work in ALL stages of the disease except once one is basically terminal from the deep damage Covid can cause in some individuals.

      • GetmesomeStromectol

        One HCQ prophylaxis study in India showed it took 4 weekly 400mg doses to start getting protection from infection. After 6 doses (6 weeks) and more, there was 80% less chance of getting infected. My thoughts are this effect might be sped up with daily 200mg-400mg intake during the first week(s).

        I don’t see why prophylaxis should not work with Ivermectin as this also accumulates in tissue/organs with a stable level during 1 week after intake and then declining during 30 days.

  13. AFM Nazmul Islam

    I have used ivermectine plus doxycycline in many of my patient was suffering from suspected and confirmed cases of covid 19. All treated patient recovered.

    • George

      What us the dosage?

  14. MD ATIKUR RAHMAN

    I shall be thankful if advised dosage schedule of Ivermectin, Zinc and Doxycycline for the treatment of COVID 19 for adult patients.
    If any dosage schedule for preventive of COVID 19 with these drugs.

  15. Dr. S.K.Purkayastha

    Pls provide doses of ivermectin, zinc, and dooxciicycline and duration of taking drugs.

    • George

      Yes please

  16. Dina

    Please help me by sending dosage of tripple therapy.

    • Deepika Dugan

      For COVID-19, 350mcg per kg body weight Adults. Not suitable for children and pregnant women.

  17. Mujibur Rahman

    I used ivermectin, ibuprofen, famotidine to more than 50 patients of suspected covid -19 infection. Prednisolone was given
    for 3 days to those who develope cough or respiratory distress. Anibiotic ( azythromycin or doxycycline or amoxyclav) was needed in some cases. Allmost all pts cured in 2 – 3 days. Elderly pts over 60 yrs required more times to recover. One pt aged 67 yr needed oxygen at home. Not a single case needed hospitalization. Twelve pts were tested with their own interest for covid19 and found to be positiv.

  18. sadat khan

    I will be thankful pls advise me I am taking 75mg Aspirin and clopidogrel 75mg and bp tablets.it ok to take your medicine as well, please advise.Thanks for your great service

  19. NR

    Already am on 3rd day of Azithromycin course after completing the course shall I start the Ivermectin and Doxycycline course I have mild symptoms

    • Sheila Gorney

      Please keep us posted. I hope you have a healthy recovery.

    • Santosh Kumar Tiwari

      Please elaborate in clear way what should be dose for kids and adults

  20. Cindy

    Where can we register interest in being a trial candidate in Aus?

  21. Linda Chuenkamon

    Am so happy to share my testimony, I am Linda Chuenkamon, I’m from Germany, Berlin. i suffer from COPD Disease for many year, thank to Herbal Health remedies Foundation for their marvellous work in my life, I was diagnosed of COPD since 2018 and I was taking my medications but it wasn’t helping much, so i seek out for some possible cure for COPD i saw a comment about Herbal Health remedies Foundation, how they cured COPD with their herbal medicine, I contacted Herbal Health remedies Foundation and they guided me. I asked for solutions, they started the remedy for my health, they sent me the medicine within 3 days. I took the medicine as prescribed by them and 2 weeks later i was cured from COPD. contact them via email once again thanks to Herbal Health remedies Foundation. Web site: http : // herbalhealthremediesfoundation . c o m 

  22. Bala Naga Bhushanamu

    Yes this medicine worked on me

  23. Maureen Bassett.

    We have all read about Professor Borody in the very beginning and noted his many qualificiations. Professor Borody : the developer of the world’s first cure for peptic ulcers which saved millions of lives world wide. Now has employed the same methodology to come up with. the Ivermectin triple therapy etc. Please, can’t we get doctors to start at least saving lives. We can go on discussing it for months and months when it appears there is a solution to getting people well again and not having to go on respirators. These drug have been approved. Professor Borody reports the combination of three approved ‘Off the shelf” drugs may point to an answer to Australia COVID-19 crises. There are many other doctor using the same drugs and having success. Surely it is medication verses ventilators in many cases. Australia can do this because these medications are approved. One cannot be clearer than that. Would Victoria like some help? The elderly have nothing to lose only to gain. Please lets get on with it and save lives and also help these who are not in danger but very unwell too. If they all get better it helps to stop the virus from spreading. It will help so many. Not only that it will have a double benefit because our economy will pick up too. All the best to everyone, I have been so saddened by all the deaths throughout the world. Everyone is special. Thank you to all the nurses, doctors, and everyone on the front line. Everyone involved. thank you so much Professor Tom Borody.

    • Nick Holden

      Maureen Bassett that is perfectly said. I am tearing my hair out with lunacy of not giving this a go.

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