UW-Madison Professor and Team To Lead The Nation’s Coordinating Center for the National Cancer Institute Cancer Prevention Clinical Trials Network

Oct 2, 2019 | Auditing and Coordinating Center (DMACC), Cancer Clinical Trials, Cancer Prevention, Cancer Prevention Clinical Trials Network (CP-CTNet), Cancer Trials, University of Wisconsin- Madison

KyungMann Kim, a professor of biostatistics and medical informatics at the UW School of Medicine and Public Health, has received a five-year, $11.8 million award from the NCI of the National Institutes of Health to set up and manage the Cancer Prevention Clinical Trials Network (CP-CTNet) Data Management, Auditing and Coordinating Center (DMACC).

What Does This Entail Exactly?

The network comprises the DMACC and three leading academic organizations across the United States—each with 10 to 30 affiliated organizations—to conduct early phase clinical trials for cancer prevention. So, this is no light task, requiring many ‘hands on deck’ as well as a high degree of skill and organization.

Nonetheless, Kim is enthusiastic, saying, “This is an exciting opportunity for me and the Department of Biostatistics and Medical Informatics to have a major impact in the nation’s program in cancer prevention clinical trials in partnership with the NCI Division of Cancer Prevention. This will also be an important component of the UW Carbone Cancer Center’s Cancer Prevention and Control Program.”

The goal of the network, as described in Mirage News, is to “assess the safety, tolerability and cancer prevention potential of agents and interventions of varying classes in order to advance their further clinical development for cancer prevention.”

More on the DMACC

The DMACC is responsible for coordinating trans-network activities and providing expertise and resources in centralized data management and reporting, clinical trials auditing and administrative and logistical coordination for the network, including providing expertise in clinical trials methodology and biostatistics.

The center collaborates with the Frontier Science Foundation in New York, which provides data management and related research support. The foundation’s mission is to advance the application of statistical science and practice and data management techniques in science, health care and education in diseases such as cancer and HIV/AIDS research, among others.

The DMACC will be housed in the Department of Biostatistics and Medical Informatics, located in the Wisconsin Alumni Research Foundation building, where two faculty members, a senior scientist, two staff statisticians, a research project manager and an administrative coordinator will work on the project.

All Hands On Deck

Anne Traynor, associate professor of hematology, oncology and palliative care at the UW School of Medicine and Public Health and faculty director of the clinical trials office at UW Carbone Cancer Center (UWCCC), will help coordinate clinical trials auditing for the center. Sue Siminski, chief executive officer at Frontier, will act as the data management and reporting unit director for the center.

“Dr. Kim and the department have been an integral part of our translational research efforts in cancer prevention and we look forward to working with Frontier, Dr. Kim and his team on this important effort in advancing cancer prevention research,” says Dr. Howard Bailey, director of the UWCCC and leader of the NCI Cancer Prevention Clinical Trials Network Consortium centered at UW-Madison.

Improving UW-Madison’s infrastructure for clinical trials is essential for research throughout the School of Medicine and Public Health, according to Michael Newton, interim chair of the Department of Biostatistics and Medical Informatics.

“The department is proud to host this exciting CP-CTNet DMACC focused on the critical task of data coordination and statistical experimental design and analyses for multi-center clinical trials,” Newton says. “It is a model for sophisticated data science in clinical research.”

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