A groundbreaking clinical trial focusing on Motor Neuron Disease (MND) has commenced, enabling patients to participate in more than one treatment at a time. Called MND-SMART, this UK-wide initiative aims to identify treatments that can slow, stop or reverse progression of this terminal disease.

Motor Neuron Disease

With no cure, Motor Neuron Disease stops signals from the brain reaching the muscles. About 5,000 people in the UK live with the disease.


Representing one of the most comprehensive clinical trials in a generation, hundreds of people in the UK living with the illness are now being invited to participate in the clinical trial. By allowing participants to test more than one treatment it could offer them a higher chance of receiving an active treatment rather than a placebo. A platform trial, this study was designed so researchers could modify their approach based on how emerging results are unfolding. Also new drugs can be added once the trial started, while ineffective ones can be terminated.

The Study Lead

The study is being led by researchers at the Euan MacDonald Centre for MND Research at the University of Edinburgh. The strategy for this study has been developed to find effective medicines quickly.


MND Scotland is one of the funders of the study and contributed £1.5 million.

Lead Research/Investigator

Suvankar Pal, neurologist, co-investigator

Call to Action: Interested in learning more about this study? Check out its funder MND Scotland

Source: ITV

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