A research team from Aarhus University Hospital, Aarhus University in Denmark and the University of Colorado investigators have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma, and HIV. The team has found that a group of transmitter substances (Cytokines) in the immune system known as the IL-1 family, play an important role in many of these diseases by regulating the body’s immune responses.
The Cytokines Expert & The Danes
Charles A Dinarello from the University of Colorado and an honorary doctor at Aarhus University is an expert in the regulation and transmission of these cytokines. Professor Dinarello discovered the cytokine known as IL-1 (-β), which plays a vital role in countless diseases. Dinarello and the Danish team came together to investigate a more efficient way of reducing the effect of the IL-1 family in the pursuit of improving the treatment of chronic inflammatory diseases.
The American and Danish teams investigated if the IL-1R3 receptor—involved with the signaling of six different inflammatory cytokines in the IL-1 family—could be a possible target in the treatment of chronic inflammatory disease. By using an antibody to block the effect of IL-1R3, the researchers could investigate the effects in both studies on cells and mice.
The team sought to understand some of the consequences of the blocking of this receptor on the immune system. Simultaneously, they sought to specifically study the effect of blocking IL-1R3 in mice with either gout, acute allergic inflammation (asthma) or psoriasis.
The experiments evidenced the possibility to effectively block the receptor and reduce manifestation of diseases, which underlines the potentials in the new approach reported investigator Jesper Falkesgaard Højen. MD and Ph.D. The results were published in the journal Nature Immunology.
The team was able to describe a new and effective approach to block IL-1 family-driven inflammation, and in this way possibly contributed a new direction to study and treat chronic inflammatory conditions driven by the IL-1 family.
Professor Charles A Dinarello, University of Colorado
Investigator Jesper Falkesgaard Højen. MD and Ph.D. at Aarhus University