Dr. Andre Krassioukov, an investigator from the University of British Columbia, at the GF Strong Rehabilitation Centre in Vancouver, BC, seeks clinical trial participants for a protocol designed to help reduce the side-effects of patients with spinal-cord injuries who depend on opioids to manage severe pain. The study team will focus on the effectiveness of a drug known as Targin among patients with spinal cord injuries.
What is Targin?
Targin is a combination analgesic drug available as modified-release tablets and consists of oxycodone/naloxone—the former being an opioid and is responsible for the pain-relieving effects while the latter opposes the effects of opioids but is typically poorly absorbed into the body when administered orally, meaning much of the dose remains in the gastrointestinal tract and reduces the local side effects from oxycodone. This combination was known to relieve patients of constipation. The drug was released in Germany in 2006 and some European countries by 2009.
The study sponsors will examine the effectiveness of Targin among individuals with spinal-cord injuries. The combination of spinal-cord injury and opioid use can make some standard protocols involving diet and laxatives not sufficient enough to offer relief, and some may with spinal-cord injuries spend 30 minutes and two hours a day managing the issue. Chronic constipation decreases quality of life and can actually be life-threatening for those people with traumatic spinal-cord injuries.
The study investigator launched the study with three patients and seeks up to 20 participants—male or female—and they must be between the ages of 18 and 65 years old and experienced a traumatic spinal-cord injury for over thee months. Moreover, they should be on an opioid for at least three months, be a Canadian Citizen, and reside in the Vancouver area.
The Research Centers
University of British Columbia (UBC)
UBC is a public research university with campuses in Vancouver, Kelowna, and British Columbia. Established in 1908, UBC is British Columbia’s oldest university. It ranked among the top three universities in Canada. With an annual research budget of $600 million, UBC funds over 8,000 projects per year. The International Collaboration on Repair Discoveries (ICORD) is an interdisciplinary research center focused on spinal cord injury. ICORD is a research center within UBC’s Faculty of Medicine at Vancouver General Hospital.
GF Strong Rehabilitation Centre in Vancouver, BC
Part of Vancouver Coastal Health, GF Strong Rehabilitation Centre is British Columbia’s largest rehabilitation center. As a freestanding facility, GF Strong Rehabilitation provides inpatient, outpatient, outreach and clinical support services to clients/patients in four unique programs, including 1) Acquired Brain Injury 2) Spinal Cord Injury 3) Arthritis, and 4) Neuromusculoskeletal.
They have offered a range of services since 1949 and are also affiliated with UBC and other academic centers—G.F. strong participates in leading rehabilitation and research.