An Ohio women reports that she is now cancer free following a CAR T-Cell therapy clinical trial being conducted at University Hospitals Seidman Cancer Center. According to a Fox News article written by Madeline Farber, Ohio-based Denise Keenan reports that ever since she participated in the trial she has been cancer free. She was first diagnosed with non-Hodgkin’s lymphoma in 2009. Farber reports that according to the National Institutes of Health (NIH) CAR T-cell therapy is a “type of treatment in which the patient’s T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added in the laboratory. The special receptor is called a chimeric antigen receptor (CAR).” In this type of study the research sponsor and sites will grow large numbers of CAR T cells in a laboratory then given to the trial’s patient by infusion.
Paolo Caimi, a hematology and oncology specialist at University Hospitals