UC Santa Barbara Researchers Compound Stimulate Lysosome & Clears Tau in Humans & Mice

Mar 31, 2019 | Alzheimer, Mice Model, Preclinical Research, Tau

University of California, Santa Barbara researchers used small molecule lonafarnib to stimulate lysosomes to clear phosphorylated tau from neurons derived from patients with frontotemporal dementia (FTD). The researchers treated Tau Transgenic mice from neurons derived from patients with frontotemporal dementia (FTD).  Treating Tau Transgenic mice with this compound reduced tau tangles in the brain and prevented behavioral problems.  This results were published March 27 in Science Translational Medicine.  The findings suggest a new therapeutic approach for tauopathies—including  FTD and possibly Alzheimer’s disease.

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