TrialWatch: SPRINT MIND Clinical Trial Links Blood Pressure & Cognitive Impairment

Feb 14, 2019 | Blood Pressure, Cardiovascular, CNS, Dementia, Positive Results

The Secondary results of Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (SPRINT MIND) study are “the first to show an intervention that significantly reduces the occurrence of mild cognitive impairment (MCI), which is a well-established precursor of dementia” according to the National Institutes of Health (NIH).

According to the study authors, it’s the first randomized clinical trial demonstrating that an intervention significantly reduces the occurrence of MCI which is an established risk factor for dementia.

A recent trial evidences a lack of correlation between low blood pressure and reduction in risk of dementia. However, lower blood pressures do lower the impact of (MCI), which does potentially have positive implications for dementia prevention. A senior investigator in the NIA laboratory of Epidemiology and Population Sciences and co-author of the study paper noted, “This is a landmark study in that it is the first trial of its size and scope to look at modified risk factor for dementia and MCI.” Ms. Lenore J. Launer continued, “The study had a carefully designed hypothesis, used approved appropriate tools to assess dementia and MCI, was blinded for diagnosis and got a good sample of old people.”

Lead Research/Investigator

Lenore J. Launer