Taiwan Researchers Identify c-MYC as Possible Biomarker for Oral Squamous Cell Carcinoma Patients

Jun 6, 2019 | Oral Squamous Cell Carcinoma, Taiwan

A Taiwan-led research team produces a study evidencing the possibility that c-MYC is a potential biomarker that can be used as a therapeutic targeting for treating oral squamous cell carcinoma (OSCC) patients with T stage (III/IV) are reported in Dovepress.

What is c-MYC?

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors.  In cancer, c-MYC is often persistently expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer. A common human translocation involving c-MYC is critical to the development of most cases of Burkitt lymphoma. Constitutive upregulation of Myc genes have also been observed in carcinoma of the cervix, colon, breast, lung and stomach.  c-Myc is thus viewed as a promising target for anti-cancer drugs. In the human genome, c-MYC is located on chromosome 8 and is believed to regulate expression of 15% of all genes though binding on enhancer box sequences (E-boxes).

About Oral Squamous Cell Carcinoma?

This cancer disease affects about 34,000 people in the U.S. each year. In the U.S., 3% of cancers in men and 2% in women are oral squamous cell carcinomas, most of which occur after age 50. As with most head and neck cancers, squamous cell carcinoma is the most common oral cancer.  The chief factors for oral squamous cell carcinoma are:

  • Smoking  (especially >2 packs/day
  • Alcohol use

Conclusion to Research

A Taiwan-led research team produces a study evidencing the possibility that c-MYC is a potential biomarker that can be used as a therapeutic targeting for treating oral squamous cell carcinoma (OSCC) patients with T stage (III/IV) .

Lead Research/Investigative Sites

  • Department of Surgical Pathology, Changhua Christian Hospital, Changhua, Taiwan
  • Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan
  • Public Health Bureau, Tainan City Government, Tainan, Taiwan
  • Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan
  • School of Medicine, Chung Shan Medical University, Taichung, Taiwan
  • Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
  • Department of Emergency Medicine, Changhua Christian Hospital, Changhua, Taiwan
  • Graduate Institute of BioMedical Sciences, China Medical University, Taichung, Taiwan
  • Environment-Omics-Diseases Research Center, China Medical University Hospital, Taichung, Taiwan
  • Toxicology and Biomedicine Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam

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