As announced in Eureakalert!, UT Southwestern Medical Center researchers have published some recent findings in Journal of Biological Chemistry:  detailing how human “cells invite inside corrupted proteins that can turn normal proteins corrupt, leading to neurodegenerative diseases such as Alzheimer’s and Parkinson’s Disease. These diseases “are associated with particular proteins in the brain misfolding, aggregating, and including normal proteins to misfold and aggregate. The researchers found that disease associated proteins bind to a sugar-protein molecule known as HSPG on the cell’s surface. The binding triggers the cell to take the corrupted cell inside.  In this study UT Southwester group wanted to further investigate this process.

Ultimately the study team seeks to understand “whether these processes work the same way in the brain as they do in the cultures of the brains.” It is hoped that ultimately we may be able to understand how corrupted proteins move between brain cells and hence one day find ways to stop them.

Research/Investigator Site

University of Texas, Southwestern Diamond Lab

Multiple other study collaborators

Lead Researcher/Investigator: Mark Diamond

Sponsors (funders)

National Institutes of Health

RWTH Aachen University

Carl and Florence E. King Foundation

Washington University St. Louis

University of Texas Southwestern

Rainwater Charitable Foundation

Cure Alzheimer’s Fund

View article here

Source: Eurek Alert

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