Real-world outcomes from treating adults with moderate-to-severe atopic dermatitis with dupilumab (Dupixent, Sanofi and Regeneron Pharmaceuticals) are similar to what researchers have found in clinical trials.

Dupilumab is generally well tolerated and the majority of patients on the drug experience clinical improvement—many benefit with complete clearance of atopic dermatitis, according to a recent report in the International Journal of Dermatology.

The Authors’ Reports

“This study provides further information on our experience with dupilumab in moderate-to-severe atopic dermatitis and its efficacy and tolerability in our patient population, further supporting the use of this therapeutic modality,” according to an email response from two of the report’s authors Sergei Grando, M.D., Ph.D., D.Sc. and Christina N. Kraus. M.D. “Our results also suggest patients may require at least 16 weeks of treatment before clinical response can adequately be assessed. To the best of our knowledge, this is one of the first reports of real-world experience with dupilumab, and our findings are well in-line with reports from clinical trials.”

Study Details

U.S. researchers retrospectively studied the medical records of 77 men and women with atopic dermatitis who were treated with dupilumab in the University of California Irvine’s dermatology department. The records from May 1, 2017 to January 25, 2019 included patients who received standard dosing, which is an initial dupilumab dose of 600 mg, followed by injections every other week of 300 mg each.

Dupilumab, FDA-approved in March 2017 to treat moderate-to-severe atopic dermatitis in adults, is a monoclonal antibody against the interleukin-4 receptor. Clinical trials have shown dupilumab is safe and effective as monotherapy or in conjunction with other atopic dermatitis therapies. All 77 patients had a documented follow-up visit within 16 weeks of starting dupilumab treatment and all had received at least one medication dose. All had tried other treatments for their atopic dermatitis.

Additional Research

The researchers in Spain looked at dupilumab treatment outcomes in 27 patients with at least 12 weeks of follow-up, noting improvements in atopic dermatitis activity and pruritis intensity. French researchers studied 241 patients and found a significant reduction in atopic dermatitis severity at three months. More than 38% of patients in that study reported conjunctivitis during treatment.

Among the patients studied, 73 used topical or systemic medications while on dupilumab. While most used topical corticosteroids in addition to dupilumab, others were treated concomitantly with crisaborole, intramuscular systemic corticosteroids, UV light therapy and topical calcineurin inhibitors.

The Importance of Real-World Studies

Real-world results suggest dupilumab is an excellent treatment modality for moderate-to-severe atopic dermatitis, as it is effective and better tolerated than other immunomodulators used in patients with atopic dermatitis, writes Drs. Grando, professor of dermatology and biological chemistry, and Kraus, resident physician in dermatology at University of California, Irvine.

Source: Dermatology Times

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