Prominent Japanese Academic Medical Center Launching Ivermectin Clinical Trial Targeting COVID-19

Sep 17, 2020 | Blog, Ivermectin, Japan, Kitasato University Hospital, News, Popular Posts

Prominent Japanese Academic Medical Center Launching Ivermectin Clinical Trial Targeting COVID-19

Distinguished Japanese professor Omura Satoshi won the Nobel prize for discovering a compound that led to the development of ivermectin. Now his university, Kitasato University Hospital, will conduct a major clinical trial to investigate whether the anti-parasite drug is a possible treatment for COVID-19. The university hospital will seek 240 COVID-19 patients aged 20 or over with mild to moderate symptoms. The intention for this study based on Japanese news: get this drug approved as an economical option to treat COVID-19.

The university formally established the basis for the study: University of Monash lab experiments revealing that ivermectin in cell culture kills ivermectin within 48 hours. Of course, TrialSite has published dozens of case series, observational studies and even the results of a couple randomized controlled studies evidencing promise for the low cost, available generic drug as a possible treatment for COVID-19. In fact, observational data reveals that ivermectin is more effective than Remdesivir, which hasn’t been able to impact COVID-19 mortality—at least not in randomized controlled studies. 

But, of course, most of the world’s press doesn’t acknowledge the couple of randomized controlled studies involving ivermectin, reports NHK World Japan (Japan’s national broadcaster).

The Study

This randomized, controlled trial will include two groups including the ivermectin group and placebo group. The hospital seeks to assess the changes in symptoms to assess the safety and efficacy of ivermectin. The Japanese university seeks 240 patients with mild to moderate COVID-19.

Operated by the Kitasato Institute, this study seeks to example safety and efficacy to secure Japanese approval for ivermectin as a treatment against COVID-19.

The Trial Site

Kitasato University is a private medical university headquartered in Shirokane, Minato, Tokyo Japan. The university is ranked by Times Higher Education among the top 350 in Asia

Kitasato University Hospital opened in 1971 as an academic medical center.

Note that Nobel prize winner Omura has served as deputy director at the Kitasato Institute; he was devoted to rebuild the laboratory while promoting the establishment of the medical center (now Kitasato University Medical Center).

TrialSite News Comments

The movement to test the safety and efficacy of ivermectin grows around the world. With nearly 40 randomized controlled studies ongoing in North America, Europe, South America and Asia major academic medical centers are embracing a growing body of real world data that ivermectin may in fact inhibit SARS-CoV-2 not only in vitro but potentially in vivo.

13 Comments

  1. MR PETER F BELL

    This article… you’d think it was last April judging by the out-dated reference to “other trials”

    The author must have missed this, google any part of it using dates AFTER August… you don’t need any more trials…there are over 4 billion doses served up of ivermectin. Any experienced Australian, Peruvian or from Senagal doctor is already using it.

    Australian Medical Director Professor Thomas Borody MB, BS, BSc(Med), MD, PhD, DSc, FRACP,FACP,FACG, AGAF, …. look for his old video/youtube.

    Ivermectin controls COVID-19 and
    also Zika, dengue, yellow fever, West Nile, Hendra, Newcastle and
    Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis and
    Avian influenza A, Porcine Reproductive and Respiratory Syndrome and
    Human immunodeficiency virus type 1,
    and severe acute respiratory syndrome coronavirus 2.”
    Stops COVID-19 in two days in early stages

    Halves the sick-time of COVID-19

    Low toxicity, no side effects used worldwide approx 4 million doses

    Can overdose by about 9 times without big issues

    Is an anti-virus… eg Dengue (river fever etc)

    Is an insecticide eg kills Scabies (but taken orally)

    Is TGA approved (Australian FDA)

    Is an anthelmintic (gut-worm killer for humans and sheep/cattle)

    May be used, (but not necessarily) with zinc, Tetracycline antibiotic and even in late stages, hydroxichloroquine.

    Sold in Australia as Stromectol.

    Single dose normally enough. eg: 12 mg large adult.

    Don’t take alchohol for at least 6 days after full dose (brain-barrier problem)

    If you notice some hospitals have less deaths and quicker in/out times it’s probably because someone is quietly using ivermectin.

    Take more care please and keep up with the latest

    Concerned… but I’m only an old grazier who doesn’t like to see all these people die when a little pill would make it all go away.

    • Sandeep Kapatkar

      Sirs, i would request a preventive dosage and repeat cycle. thanks

      • Bhupesh Dewan

        The prophylactic (preventive) dose of Ivermectin is 12mg once weekly. For those with body weight below 40kg, it may be taken as 6 mg once weekly. Once weekly dose is based on the long half life (approx 18 hours.) of the drug.

        • Philip McDunnough

          The 12 mg weekly preventative dose sounds interesting. Would this change with zinc? Has anyone combined this with another zinc ionophore, such as Quercetain or even HCQ ( for prevention)?

      • MR PETER F BELL

        Thank you sir… I did note that you should have a good look at Dr. Borody’s video where he spells out that for preventative dose just halve it or email him for complete dosage recommendation; he provides his address.
        In Australia we can get it prescribed by our doctor … it is called Stromectol here.
        There is now another convincing video/Q&A you should see:
        https://www.youtube.com/watch?v=RDzBdDhyJzI or google “Ivermectin Talk with Adam Gaertner”

    • Philip McDunnough

      Interesting. Is the dose similar to the zinc, doxycycline, Ivermectin cocktail used by Professor Brody?

      The Dominican Republic seems to give it for 3 days ( 6 mg twice a day) along with zinc and Azithromycin.

      Unless testing is convenient, a nice preventative scheme would be nice. Any thoughts? The problem with treating things that develop after being exposed is timing. You have to get things early, which isn’t always obvious.

  2. Walt

    Finally the Nobel prize winner who essentially discovered Ivermectin and his university are stepping up and getting involved. It will be impossible for the academic and scientific establishment to ignore the results of his study. This will be make or break for Ivermectin. Positive results and Ivermectin will be embraced by doctors around the world. Inconclusive or negative results will end the possibility of mainstream use to treat COVID. Where is Merck in all of this. Shameful. Great reporting as always TrialSite.

  3. Dennis Abrameit

    I contacted Merk the company who owns ivermectin and asked a nice lady on the phone about them getting behind clinical trials with ivermectin against the carona virus. She said after leaving me on hold and asking me to spell ivermectin that the trial invitro with a huge amount study made them not want to test it for Corona virus.Im learning but I’m not going to be able to make them change their mind but maybe you guys could. I dialed 1-800-672-6372 here in the USA

    • Walt

      Wow, now that makes me really nervous. I wonder about the competence of these large pharmacy companies. Merck does not even realize that the dosesge of in vitro tests often has little to do with the actual doseage required for real subjects. Given all the positive studies they should be leading on this,

  4. Paul Elkins

    Great to see Japan jumping into the Ivermectin camp with a well designed RCT! All additional evidence helps force the hands of the regulatory bodies. Any idea of the estimated primary outcome date or study completion date? Can’t come soon enough!

  5. Randolph W Lievertz, MD

    I hope that doses larger than 12 mg will be studied. In vitro and animal data suggest that 1 mg/kg body weight is the most effective anti-viral dosage.

    I am eagerly looking forward to seeing the study data.

    • Bhupesh Dewan

      18mg per day dose is being studied in Argentina.

    • Philip McDunnough

      1 mg/kg sounds really high. Isn’t the dosage for horses, etc… similar to that for humans at 200mcg /kilo? Human recommendations in North America drop to 150 mcg/kilo.

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