Omega Therapeutics announced the completion of $85 million financing nearly one year after launching. The funding will support progression to first-in-human clinical trials of the company’s Epigenomic Controllers for programs in oncology, inflammation, autoimmune, metabolic, and rare genetic diseases.
“We are advancing the frontiers of medicine through epigenomic programming,” said Mahesh Karande, President and Chief Executive Officer of Omega Therapeutics. “We have engineered novel therapeutics that enable controllable epigenomic programming leading to single and multiple gene modulation. We have therapeutic programs in immunology, oncology, metabolism and other disease areas where our precision genomic modulation approach allows us to go after historically ‘undruggable’ targets,” Mr. Karande continued. “Our approach utilizes well-proven aspects of mRNA-based therapeutics as well as drug delivery. We are privileged to continue the Flagship tradition of pioneering innovative genomic medicine-based therapeutic platforms with the potential to generate multiple products, the first of which we plan to have ready for the clinic in 2021.”
Omega’s epigenomic programming platform is focused on selectively directing the human genome to treat and cure disease by precisely controlling genomic expression without altering native nucleic acid sequences. Omega has created a proprietary platform and knowledge base that identifies Insulated Genomic Domains (IGDs) and their biological functions in both healthy and diseased states across cell types. IGDs naturally function as the fundamental regulators of the human genome and can be modulated to up- or down-regulate single or multiple genes simultaneously. These scientific and product insights drive the discovery and development of disease-specific genomic modulators called Epigenomic Controllers, which are engineered to precisely tune genomic activity to desired therapeutic levels with high targeting specificity and durability of effect.
“Our Epigenomic Controllers comprise a DNA-binding domain and an epigenetic effector domain delivered as mRNA to modulate gene expression. Besides treating monogenic diseases, our therapeutics can, for example, target and modulate difficult-to-drug oncogenes and growth factors, treat complex multi-genic diseases, and control cellular programming and differentiation,” said Thomas McCauley, Ph.D., the company’s Chief Scientific Officer. “A single intervention allows us to modulate single or multiple genes to the desired therapeutically-relevant level with high specificity and a controlled duration of effect through epigenomic programming. This is Precision Genomic Control™ at its best.”