Northern Indian State of Uttar Pradesh Drops Hydroxychloroquine & Replaces with Ivermectin for COVID-19 Patients

Aug 8, 2020 | Coronavirus, COVID-19, India, Ivermectin, News, Popular Posts, Uttar Pradesh

Northern Indian State of Uttar Pradesh Drops Hydroxychloroquine & Replaces with Ivermectin for COVID-19 Patients

Leadership from the great northern Indian state of Uttar Pradesh, home to the Taj Mahal, has decided to approve the use of ivermectin as a treatment and prevention of COVID-19. The drug will be used instead of hydroxychloroquine. Moving forward, ivermectin will be allocated to frontline health professionals treating patients in hospitals serving COVID-19. Yet another positive data point for the use of ivermectin as one approach to fighting COVID-19. Will the Western press care?

As reported in DNA India and multiple times in TrialSite, ivermectin is being successfully used across India as one economical way to stem the onslaught of the pandemic. Hospitals and institutions from AIIMS, Lady Hardinge Medical College, and Max Hospital to Lok Nayak, now routinely administer ivermectin to COVID-19 patients. The Indian Express reports that the switch and acceptance of ivermectin came as the result of positive results from a study at Agra.

Usage Grows

If press accounts are entirely accurate, the health department in Uttar Pradesh and elsewhere are prescribing the anti-parasitic drug, even to those who just come into contact with COVID-19 patients, in a bid to prevent a more severe infection from occurring.

The Drug

Often known as the “wonder drug,” the anti-parasitic drug is used to target parasitic infections from head lice and scabies to river blindness and other tropical diseases. The Monash University lab experiment started the interest in the drug as a treatment for COVID-19. In parts of the world where large pharmaceutical companies hold sway, the press avoids discussion of the drug.


DNA India raised a sample study conducted by Xi’ a Jiaotong University centering on 116 subjects who tested positive for COVID-19. The combination of ivermectin with doxycycline produced “far superior” results in the hydroxychloroquine and azithromycin therapy comparator in mild to moderate COVID-19 infections. TrialSite is now known worldwide as a chronicler of ivermectin research—search TrialSite for the many observational and randomized controlled studies ongoing.

ICMR Started Investigating Ivermectin in June

TrialSite reported that India’s ICMR commenced studies into ivermectin just a couple of months ago. The apex research agency investigates the U.S. FDA approved anti-parasitic drug as reported by ICMR scientist Nivedita Gupta.

Lack of Intellectual Curiosity is Telling

There is some form of press censorship on the topic of ivermectin. The only rumblings coming out of the U.S. or “West” is that it isn’t proven, used for animals, or could be dangerous in higher doses. No one declares it’s been called the “wonder drug” and that billions of prescriptions have been given in tropical countries. There is an unbelievable lack of intellectual curiosity, which only raises the interest levels for independent media platforms such as TrialSite

What if all of these observational and case studies that purport positive results are representing truthful scenarios? What if the drug could, as is claimed by dozens of doctors interviewed, cut the time of infection down by, in some cases, 50% (note this is significantly superior to remdesivir if true) as well as the death rate?

There are major universities (University of Kentucky/Johns Hopkins University) in the United States conducting ivermectin studies. A study (albeit an observational one) at Broward County Health revealed materially beneficial results, including a lower death rate. 

Why would MedinCell, a company that has received grant funds in the past for malaria work from the Bill and Melinda Gates Foundation, plan to commercialize for COVID-19? Why would a top tropical health key opinion leader at Sheba Medical Center in Israel invest his and Sheba’s time in a randomized controlled trial?

How about the Leona M and Harry B Helmsley Charitable Trust (Helmsley Trust) in New York awarding funds to Monash University (again the first lab to study ivermectin in the context of COVID-19) to start identifying optimal dosing for clinical trials? Or, for that matter, a prominent Australian researcher, Thomas Borody, coming right out and declaring that the triple therapy of ivermectin, doxycycline, and zinc works to reduce the impact of COVID-19? Is he just a quack?

About 30 randomized controlled studies are ongoing, and a few of the results have been positive but not picked up on by any significant Western press. TrialSite has accumulated enough data points to take the position that some Western biopharma companies should investigate. TrialSite has committed top clinical trials monitoring resources to an effort in Florida to conduct a clinical trial: the momentum is growing to get such a study going via several hospitals in the United States. 

There are too many data points not to. Even the FDA supports such an effort as they called out in their informational about ivermectin that randomized studies need to be undertaken.

But the lack of interest, despite numerous data points from around the world, has truly perplexed the mind. Unless the prospect of an economical and available treatment disrupts monetization imperatives? Or perhaps even a more primordial resistance from research elites?

But what if the first generation of vaccines have only limited impact? As reported by CNBC, Dr. Fauci is recently on the record that the chances of a vaccine working well, or being “highly effective,” is “not great.” 

The economic, social, and political consequences of not having a broad-based, methodical and effective, multifaceted approach to deal with this pandemic, assuming no vaccine, are too great. TrialSite only advocates that at least one of the prominent Western biopharma step up and investigate ivermectin as possibly one way to more economically contribute to a multifaceted pandemic containment strategy. It isn’t a panacea, and it isn’t a cure. But the implication for not incorporating a more pragmatic approach to pandemic controls will convert to staggering public expenditures, including the massive transfer of public monies to the private sector. The taxpayer will ultimately be called on for repayment. 

Source: DNA India


  1. ML

    Truly appreciate your reporting on this issue, TSN. A million thanks to you and to all those brave clinicians who help their patients without regard to political pandering to Big Pharma.

    • TrialSite

      Thank you very much.

  2. William A Latimer

    You should know that Johns Hopkins has dropped recruitment in their proposed Ivermectin study.

    • TrialSite

      Thanks William, we really appreciate this. The study seemed to be stuck for a while now it sounds like they dropped recruitment. We will inquire to determine what happened. Grateful for the information.

    • Ram Bahadur

      max and other hospital didn’t publish thier trial paper yet.
      still up government have given permission for use ivermectine in treating covid19 patients.
      what is the matter?

      • TrialSite

        Ram TrialSite has an inquiry into CDSCO. They have issued public statements on Favipiravir, convalescent plasma, but no word on Ivermectin. In the meantime we reported ICMR was investigating the antiparasitic drug. We have reported that several hospitals have accepted off-label protocols and some state health agencies apparently have bought into this.
        We will continue to probe CDSCO for more information.
        Thanks for the visit!

  3. Ram Bahadur

    it is really good sign.

    • Dennis Abrameit

      I read somewhere about dosages being the problem.Why not just use the same dose of ivermectin as you would use treating the other diseases it’s prescribed for

  4. Louis F Brichetto

    The simple answer is that there isn’t big pharmaceutical money in Ivermectin because the patent has expired and anyone can make it

    Big pharmaceutical would have a financial lock on any new treatment or vaccine.

    All about the Money


    “Take Tylenol”

    That’s the more or less official treatment for Covid-19 in America. If you call a hotline and report classic symptoms or a recent positive test, there is no recommended treatment for early disease.

    I think that is inadequate, a missed opportunity to head off an ER visit, hospitalization, long-term morbidity or death.
    Why? It’s obvious, Big Medicine wants the business, they don’t want you to die but they certainly want you to need expensive medical services. They want heads in beds.

    Big Medicine got out front on this epidemic and shaped our reaction to their advantage. I’m a Family Practice Doctor and the big problem to me is that I don’t get to do my job. People were/are told to call or drive thru testing areas and stay out of their doctors’ office. Based on a big body of evidence from previous viral respiratory diseases, we can estimate that a visit to your PCP will reduce the risk of hospitalization (etc) by about 25-40% even if no specific intervention is employed. But potential patients are basically not allowed to visit their PCP.

    Establishing a therapeutic alliance with a patient and clarifying a path forward and instilling positive expectations is a tangible real-world benefit. This is precisely the benefit designed to be removed by Randomized (blinded, placebo-) Controlled Trials (RCTs) so that only the intervention’s effect can be measured. More importantly, specifically formulated RCTs (Phase 1-3) are required to get FDA approval for a patented intervention. Ethically, is it right to let a few million people die while we wait for Big Medicine (Big Pharma) to do it’s thing?

    Think about what you hear or read or see from The Media. Do they say what they used to say about almost everything (“See your doctor.”)? Or is the conversation centered around scary statistics, overwhelmed care facilities, RCTs and future vaccines and things never mentioned a year ago?

    Summarizing the theme: Big Medicine sees Primary Care Providers as drug-prescribers, referrers and chart-keepers for which they are grateful. However, if a PCP endeavors to head off an illness before it becomes expensive, he/she becomes the enemy. Big Medicine has definitely won the first battle.

    Part 2:

    It is highly realistic to expect that an infected person will reduce his/her risk of a bad outcome by 30-50% by visiting their PCP early in the disease process. Or even better, see their PCP ahead of time to prepare: work on fixing their fatty liver or faulty immune system and dietary deficiencies and maybe even pre-purchase a few interventions.

    I would love to get back in the game and see patients, especially before they are exposed to Covid-19. As I do anyway, I would review their diet for vitamin and mineral content and their Vitamin D sourcing for adequacy. (I have asked all my patients to take Magnesium and Vitamin D3 as supplements for the last 10 years unless they have a better plan. More than half of Americans are insufficient in both, cost is about $20/year to correct.) I would ask them to take N-Acetyl-Cysteine (NAC) 600 mg twice daily in the hopes it works as well for Coronavirus as it does for Influenza H1N1 and RSV (I suggest this to all my patients for flu season anyway). Nowadays, I would ask some or most of my patients to take a zinc supplement and maybe vitamins A, C and E depending on their current diet and other health issues. Regular exercise and avoidance of high-glycemic foods (flour is enemy number 1) is always important.

    I’m not certain what to recommend to patients who just contracted the infection. It’s a golden opportunity that I would like to optimize. What exactly is/are the treatment regimen that non-Western doctors prefer? I won’t recommend or prescribe anything that fails any of these 4 criteria: several decades of safety data, low cost, convenient, might help.

    For early disease with or without symptoms: I currently would go with Zinc 50 mg twice daily (or Cold EEZE lozenges if tolerated for both topical and immune function benefit), Ivermectin 200mcg/kg/day for 3-5 days, LABA/ICS inhaler if coughing, and maybe a macrolide (clarithromycin over azithromycin if sputum production for it’s mucolytic superiority) or doxycycline depending on the patient’s view of antibiotics. Low dose Dexamethasone has long been my favorite “active-placebo” for viral illness. This presumes vitamin and mineral deficiencies have already been addressed. Famotidine too? Comments?

  6. Natalie

    Why this treatment isn’t being rolled out immediately is baffling!! Thank you so much for reporting on this and I hope that your efforts help to spread the knowledge far and wide!

  7. ML

    Dr. Keizer, your post was a spot-on perfect description of the state of affairs regarding Covid in the USA. I like your treatment plan, too. I would definitely recommend Ivermectin, probably 12 mg a day for 2-3 days and the zinc as noted in your post. I would also hope that my patients’ serum vitamin D levels would have been checked as a baseline long before this, as I prefer patients to have a serum level in the 60-70 range for optimal immune function. I would probably add in doxy or Azithromycin as well and would have had them taking NAC 600 mg bid for amelioration of any viral respiratory illness they might come across. Inhalers as needed, both albuterol for rescue and budesonide as needed. Perhaps an aspirin or baby aspirin a day while ill due to Covid’s tendency towards micro clots everywhere, as long as there are no contraindications. I also recommend patients take Quercetin daily, 500 mg bid as this is a zinc ionophore and although studies are sparse, it cannot hurt to allow it to help zinc into the cell and hopefully disable RNA-dependent RNA polymerase. I’d probably ask them to take some Pepcid too. Quite a bit there, but something must be done to keep them from proceeding into catastrophic illness this virus can cause. Are you able to contact patients by phone and bill for a visit and talk to them about all these important issues? My practice is doing this. Thanks for your post. M

  8. Billy Goddamn Willis

    Of course the US is mum on ivermectin or telling people it doesnt work and studies are being dropped…its hard to get rich off something cheap that’s already around and plentiful….that page is not in the playbook….

    • TrialSite

      Hi Billy good to hear from you.
      You know we can’t be certain as of yet but it certainly appears to be a factor or element.
      Observational real world evidence is a good thing–the FDA has touted it as a key complementary approach to RCT. We are accumulating ever more RWE in regards to Ivermectin. At the very least it should at least be investigated.
      But we think there is something even deeper than money going on as well. Afterall world economy is in deep trouble and big pharma companies do not rule the world. So there are other factors going on here as well; deeper more primordial forces that are inhibiting insiders from coming forward to even have an open intellectual discussion.
      Thanks for the visit to TrialSite.

    • TrialSite

      Hello we are monitoring and have sent the investigator a request for an update. We will send another note.
      Our concern is that no one wants to publish. Hope this isn’t the case.
      Regards Publisher


    ML, Thanks for your response!! I had forgotten about adding aspirin, very good idea (It’s the only medication my PCP recommends, actually) I like the Quercetin idea also, maybe for people who haven’t been taking zinc and building up their reserves already.

    For what it is worth, my Vitamin D3 advice is 10-20,000 IU per WEEK (e.g. 5000 IU capsules X 4 at once, one day a week) when not tanned and 5000 IU per week if tanning in the summer. This is for normal weight (BMI under 27). Those with extra adipose tissue may need much more as vitamin D seems to disappear into fat cells and never come back. (Add at least 5000 IU per week per 50 lb over ideal body weight.) Those who have not been supplementing should perhaps double the dose for 8 weeks to catch up.

    When my exposure comes, I plan to steal the Ivermectin from my dog who takes it monthly for heartworm prevention. Her version is sold for horses at Tractor Supply for under $5 per tube of apple-flavored paste with enough medication to treat a horse for a day or a person for 5-7 days or a dog for 10 years. It will be convenient for me as there is a calibrated plunger and the human dose is the same as for horses and pigs, 200mcg/kg body weight/day. (The dog dose is much lower). I certainly would not advise my patients to take a drug labelled for veterinary use only, as I would be happy to prescribe it for them. It is only a little more expensive by prescription for humans and you don’t have to eat hay afterwards.


    If this is an appropriate blog site for non-partisan politics, here goes:

    The major cause of death in USA is lifestyle disease. While Covid-19 will be responsible for 10-15% of the deaths in USA this year, lifestyle disease will still be killing 3-5 times as many, depending on how you classify. Is lifestyle disease getting proportional coverage in the news?

    Let’s put it this way, 3000 or so people die when 2 buildings fall down in NYC. That’s been in the news off/on for 18 years. More than that many people die needlessly every week, nearly everyday, from overeating processed food and undereating real food. How often is that in the news? That it isn’t “news” is perhaps one justification for not hearing about it but by now Covid-19 isn’t “news” either.

    Malnutrition is the elephant in the living room. Over half of Americans are overweight, 30-40% have fatty-liver disease, most Americans will develop insulin-resistance or pre-diabetes or diabetes depending on where you draw the line between normal and disease. Big Medicine has responded by treating the symptoms for money and not addressing the underlying causes.

    I ask the medical students I teach what their medical schools are telling them to do to address the epidemics of obesity, diabetes and knee arthritis. The answer is “we can refer patients to a nutritionist”. I have been flat-out told by my hospital’s medical student coordinator to not talk about nutrition or non-prescription supplements in front of the students. His reasoning is sound: “It’s not on their tests. Why would they care? You’re wasting their time.”

    Everybody should know that they are likely to be deficient in Vitamin D and Magnesium. Search NIH website and see how many people get the Daily Value of these and other minerals. Not many. So I tell patients, “It’s everybody’s job to know that they need to take Vitamin D3 and magnesium (or change their diet to get enough) but it is nobody’s job in society to tell you.” So I tell them and for most it’s the first they have heard. Check it out, Vitamin D deficiency and magnesium-dietary insufficiency are the 2 most prevalent diseases in America. How aggressive have doctors been in treating these disesases? It costs about $20 per year and (based on a variety of models I have looked at) will add a year or 2 to your lifespan.

    These 2 “diseases” or “conditions” are multipliers of many other disease symptoms for which Big Medicine makes a lot of money. Mental illness, infection, diabetic complications, arthritis… A long list. So the principle is simple: Why prevent a disease for very little money when you can make a lot more money by letting it progress?

    A simple justification is semantics, if you call them “conditions” instead of diseases then doctors don’t have to concern themselves. The FDA approves tests and medications for “disease”. Somehow doctors have evolved to only TREATING disease and are no longer in the business of PREVENTING disease.

    Guideline committees only discuss FDA approved TREATMENTs. Nothing about prevention. Not much about “conditions” pre-disposing to disease You can think yourself a good doctor by just following guidelines.

    Part 2:
    There is a rigorous pathway to getting FDA approval. It’s costly and difficult but the main principle is the Randomized Control Trial (the word “double-blinded” should be in there but the degree of successful blinding is no longer reported, those involved in studies know how often patients and evaluators are unblinded by classic side-effects, etc and are able to instill expectations on participants). The culture of all of Medicine has shifted to where only RCTs count as evidence and everything else can be dismissed. It’s perhaps fair for Big Pharma to say, “If we have to do it to prove our product, then you have to do it too.”
    This discounts years, even centuries of accumulated knowledge. The big theme of the middle of the 20th Century was fixing nutritional problems. Millions of Chinese died annually from beriberi until thiamine sources were introduced. Refrigerated trucks and interstate highways made it possible to fix these problems for most Americans. As a child of the Cold War, I well remember the emphasis on eating well and exercising to stay strong to compete with the commies.
    Supermarkets had posters sponsored by the USDA educating mothers on how to feed their families. The Ad Council educated us on television. The media and public schools were involved, we learned the 7 or 4 basic food groups and consciously designed meals around these principles.
    The government fixed several problems by mandating “fortification” of foods, notably iodine in salt and Vitamin D in milk. More recently, the paucity of nutrition in grain was partly rectified by “enrichment” with some B vitamins. Nutritional disease was never conquered but was mostly quelled, at least for those who could afford a variety of foods and kept their diet balanced.

    Nutritional disease is complicated and multi-factorial. There is a wealth of data and studies, more outside the USA than in, and accumulated for over 100 years which may direct us. But the evidence is not in the form of RCTs so it can be ignored. Even prospective studies like Framingham no longer get credence.

    Now that nutritional deficiencies have crept back with a vengeance, who is addressing them? With Big Medicine/Pharma making Big Money by partly treating the consequences yet several thousand Americans still dying early every day from poor nutrition, who gives a ________?

    These are rhetorical questions. I don’t have answers. Does anyone else?

    • TrialSite

      One correction: TrialSIte isn’t a blog but fully integrated, 100% independent media platform with a compelling research-centered social network released soon to the market.

      This is a non-partisan media site in that we don’t advocate one corrupt party over another one.

      But rather TrialSite represents a platform for our network—you– to try to introduce more truth, more accuracy, more balanced and objective perspective. This isn’t always possible but we try.

      You share a provocative perspective and while it will take time to digest everything there is certainly striking wisdom emanating from Dr. Keizer! We most certainly have been on record that we don’t have a health care system but rather a “sick care” system.

      We are grateful for your visit.


  11. ML

    Rick, funny you should say that…. I have Ivermectin Horse Paste myself and plan to dose myself and family this way should the need arise… I laughed out loud at your response. The therapeutic dosing range is wide enough not to worry about your average Joe getting into trouble with it, should their doc be less inclined to actually help someone who wants more help than just, “Go home, rest and take Tylenol!” I like the plunger dosed by weight in pounds, each hatch mark around 50 pounds of body weight. I have a friend in Arizona who came down with symptoms, got tested at her doc’s office that day and was told just that. Being in the know, she contacted her Mexican doc friend and he overnighted her human grade Ivermectin and Azithromycin, told her to take an aspirin a day and also asked her to take Loratadine… not sure why that was added. Anyway, this is just an anecdote, but her fever was gone in two days and she was well in five days. And her Covid test… well, that took TEN days to result! It’s hard to believe The Media isn’t talking about this, but when you think of what we are all up against in this country with your description, it’s really not surprising, though it is enraging. I agree with your vitamin D protocol. Most patients I test in the Pacific Northwest have serum levels in the teens or below ten. I myself take 5000 units a day and I do so all year long and have never had a lab value over 66 with this plan. So glad there are other sane FP folks who will actually help our patients survive and thrive. Cheers to you and best of health! M

Pin It on Pinterest