As reported in the Institute for Research in Biomedicine (IRB Barcelona) over a million people annually are diagnosed with colon cancer.  Chronic inflammation represents one of the main causes underlying the disease’s development.  “Scientists headed by ICREA researcher Angel R. Nebreda at IRB Barcelona report a new mechanism that contributes to the development of inflammation-associated colon cancer and points to new therapeutic targets.”  Recently published in the journal EMBO Molecular Medicine, “our study demonstrates that the capacity of myeloid cells to enhance tumorigenesis is determined by the protein p38. In particular, we have identified an important contribution of the hormone IGF-1, which is activated by p38 in myeloid cells,” explains Nebreda, head of the Cell Sigalling and Cell Cycle lab.”

Lead investigator Angel Nebreda profile

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Source: Science Daily

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