Cincinnati Children’s Hospital and St. Jude Children’s Research Hospital in Memphis, TN have received commitments from National Institute of Allergy and Infectious Disease (NIAID), with awards totaling more than $64 million over the course 7 years to support studies.
These NIAID awards will support critical observational studies of infants to challenge the understanding of how immunity to influenza develops and evolves over time. The funds are allocated to support the effort to generate a comprehensive understanding of “immunological imprinting” and how this can inform the formation of improved protective influenza vaccines.
$34.3 million over 7 years to St. Jude Children’s Research Hospital and Aubree Gordon, PhD, of the University of Michigan School of Public Health. This study is designed to follow more than 3,000 infants and young children from Los Angeles and Managua, Nicaragua and Wellington, New Zealand.
$29.9 million over 7 years will fund a study of more than 2,000 infants and their mothers from Cincinnati and Mexico City for at least three years. The study will be led by principal investigator Mary A. Staat, MD of Cincinnati Children’s, and will use weekly clinical visits to gather valuable data about the changes in the immune systems of the participants.
Both of the studies will include the regular collection of nasal swabs and blood samples from the participants to learn more about B-cell and T-cell responses and function, the antibodies produced, and other changes as children are exposed to influenza viruses and vaccines.
Mary A. Staat, MD of Cincinnati Children’s
Aubree Gordon, PhD, of the University of Michigan School of Public Health