An international research team led by Karolinska Institutet in Sweden reports on a study providing insights into the regulatory T cells’ role in protecting against autoimmune disease. The Swedish-led team was able to show that regulatory T cells control immunotolerance in the gut and their recent results were published in the Journal of Allergy and Clinical Immunology.
The researchers mapped targets of the immune system in patients with a rare disease IPEX. Patients with this disease lack regulatory T cells and develop serious autoimmune diseases in which the immune system attacks the body’s own tissue, such as type 1 diabetes, enteritis and dermatitis. In studies of 17 patients with IPEX, the Karolinska Institutet has been able define which self-molecules are targeted by the immune system when regulatory T cells are lacking.
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Lead Research/InvestigatorSource: Eurek Alert