University of Michigan News reports that “Michigan Life Sciences Institute have uncovered potential new role for long noncoding RNA in obesity and nonalcoholic fatty liver disease—an accumulation of too much fat in the liver that affects an estimated 64 million Americans and increases their risk for cirrhosis and liver failure.  According to an Intermountain Health Study fatty liver represents $32 billion per year annually in health care costs.

According to the University’s press release “Working in mouse models, the researchers identified a specific type of long noncoding RNA (also called lncRNA) that increases fat accumulation in the liver and exacerbates fatty liver disease. The findings, scheduled to publish July 30 in Nature Communications, offer clues to the drivers of the disease in humans.”

Research/Investigative Site:

University of Michigan Life Sciences Institute

Lead Research/Investigator:

Jianide Lin

Sponsor:

National Institutes of Health

Study authors were Xu-Yun Zhao, Tongyu Liu, Lin Mi, Xiaoling Peng, Crystal Rui, Liang Guo, Siming Li and Jiandie Lin of U-M; Xuelian Xiong of U-M and Fudan University, China; and Xiaoying Li of Fudan University, China.

 

Source: University of Michigan News

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