As reported by Alison Rodriguez in AJMC, Acute lymphoblastic leukemia (ALL), the most common type of childhood cancer, as well as fractures from osteoporosis represent a material cause of morbidity in patients with ALL. This study sought “to document the annual incidence and predictors of fractures in order to determine whether they occur years after chemotherapy.”
Published in the Journal of Bone and Mineral Research, 10 children’s hospitals in Canada were used from 2005 to 2007. Patients were enrolled through the hospitals’ oncology clinics. 186 children with ALL were enrolled in the study.
“In revealing that vertebral fractures are frequent in children with ALL on chemotherapy, and that older children and those with more severe collapse are at risk for residual vertebral deformities, strategies to prevent vertebral fractures in those at greatest risk for permanent sequelae now merit further study,” concluded lead author Leanne Ward, MD, of Pediatrics Children’s Hospital of Eastern Ontario.
Study lead Leanne Ward, MD, Pediatrics Children’s Hospital of Eastern Ontario and Associate Professor and Director of Bone Health Program, University of Ottawa, Canada
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