Home CNS Columbia Univ. Study Reveals Depressed Brain & Gut Mediated by Serotonin

Columbia Univ. Study Reveals Depressed Brain & Gut Mediated by Serotonin

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A new Columbia University Medical Center study suggests that some forms of depression and gut distress arise from the same glitch in neuronal chemistry—low serotonin. The findings from the study were recently published in Gastroenterology through an article titled “Effects of Serotonin and Slow-release 5-HTP on Gastrointestinal Motility in a Mouse Model of Depression.”

The preclinical study in mice revealed that a shortage of serotonin in the neurons of the gut can cause constipation, just as a serotonin shortage in the brain can lead to depression.  Quite surprisingly, the researchers found that if serotonin levels are raised in the gut and the brain both conditions may be alleviated.

Lead Research/Investigator

Karen Gross Margolis, MD, associate professor of pediatrics, Columbia University Medical Center

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