The College of Medical Sciences, Bharatpur, Nepal, conducted a study that links Hidradenitis suppurativa (HS) with thyroid disorders. Apparently, a significantly higher prevalence of thyroid disorders was found among patients with HS and a research letter published in the Journal of the American Academy Director encouraged more research.

The Study

The team from Nepal utilized PubMed, Scopus and Cochrane databases to analyze data associated with thyroid disorder and HS. The team reviewed case reports, reviews and studies without controls excluded. Ultimately, they focused on six studies encompassing 39,748 patients with HS and 206,967 controls were included.

As reported in Healio by Abigail Sutton, there was an overall higher prevalence of thyroid disorders in patients with HS. But the researchers reported that the findings were statistically significant in only three studies. Also, heterogeneity was determined significant. The researchers did not reveal any publication bias.

They found a significantly higher prevalence of thyroid disorders among patients with HS (OR = 1.88; 95% CL 1.25-2.81).

Investigator Comment

Prakash Acharya, MBBS, MD; and Mahesh Marthur, MD, DCP, both co-wrote: “Although HS is thought to be an autoinflammatory disease in contract to the autoimmune nature of thyroid disorders, production of inflammatory cytokines such as (tumor necrosis factor) ]-alpha and [interleukin]-1 beta  in HS could trigger the autoimmune process of thyroid disorders in susceptible individuals.”


The study was not able to accomplish subgroup analysis based on severity and duration of HS due to inefficient data. Another limitation involved the fact that separate analyses according to the type of thyroid disorder were not performed and presents another limitation.

Lead Research/Investigator

Prakash Acharya, MBBS, MD 

Source: Healio

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