By regulating the JNK and ERK1/2 phosporylation the gene PPP5C promotes cell proliferation in human prostate cancer. PPP5C was highly expressed in PCa tissue as analyzed by immunohistochemistry and ONCOMINE datasets. PPP5C Knockdown inhibited cell proliferation and colony formation in PCa cells. Flow cytometry analysis showed that DU145, PC3 and 22RV1 PCa cells deprived of PPP5C were arrested in G0/G1 phase and became apoptotic. Western blot analysis indicated that PPP5C knockdown could promote JNK and ERK phosphorylation. The researchers concluded their study by indicating that the PPP5C may become a new potential diagnostic biomarker and therapeutic target for the PCa.
Department of Urinary Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Department of Urinary Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Department of Urinary Surgery, Third Affiliated Hospital, Second Military Medical University, Shanghai 201805, China
Department of Urinary Surgery, Gongli Hospital, Second Military Medical University, Shanghai 200135, China