Researchers from China’s Children’s Hospital of Soochow embarked on a study to investigate the potential role of CTRP3 in obese children and explore its relationships with insulin sensitivity, pancreatic β cell function, and obesity-related markers.

What is CTRP3?

CTRP3 is a novel peptide that has recently emerged as an important regulator adipokine of obesity and related metabolic disease. Apparently, the Chinese-based team sought out to investigate this peptide as little is known about its role in children

The Study

The team led by Children’s Hospital of Soochow studied the levels of serum CTRP3 in 48 obese and 36 normal weight pre-puberty children. The levels of blood pressure, lipids, glucose, and insulin were measured, and the values of HOMA-IR, HOMA- β and insulinogenic index were calculated. These correlations of these measurements with CTRP3 levels were analyzed reported Dovepress.

The Results

The team from Soochow found that CTRP3 serum levels go down in obese children compared to the controls in the clinical study, and insulin-resistant obese subjects have lower CTRP3 in contract with the non-insulin resistant obese subjects. Moreover, serum CTRP3 concentrations significantly decreased, while glucose and insulin concentrations significantly increased after a 3 hours oral glucose tolerance in obese children. Additionally, serum CTRP3 levels correlated negatively and significantly with BMI, triglycerides and systolic blood pressure, fasting insulin, glucose, HOMA-IR, HOMA β and insulinogenic index in obese children.

Conclusion

CTRP3 levels significantly decrease in obese children, and negatively correlated with insulin resistance and pancreatic β cell function indicators. Therefore, CTRP3 may play a protective role in the glucose homeostasis and tightly regulated to β cell function as well as obesity-related markers in obese children.

Lead Research/Investigator

Miao Hou, Department of Cardiology, Children’s Hospital of Soochow University, telephone 86-512-8069-3506; email houmaio@321@126.com

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Source: Dovepress

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