As reported in EurekAlert! researchers at Stanley Manne Children’s Research Institute at Ann Rogert H. Lurie Children’s Hospital of Chicago and colleagues used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis (CF). Such patterns of gene expression ultimately could help predict disease severity and treatment response, and therefore lead someday to therapies tailored to each patient’s precise biology.
Cystic Fibrosis is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. A genetic disease, people with CF have inherited two copies of the defective CF gene, one copy from each parent. Both parents must have at least one copy of the defective gene.