Over a decade ago, French researchers from the Department of Dermatology with INSERM, CHU Hotel-Dieu, reported that they conducted a small pilot study using zinc salts on Hidradenitis suppurativa patients. The small study showed some promise in that 36% of the patients experienced total remission. They found that zinc salts could offer a new therapeutic alternative for the treatment of hidradenitis suppurativa.

Retrospective Chart Review

In a retrospective chart review, researchers from Germany’s Ruhr-University Bochum evaluated the combination of 90 mg/day oral zinc gluconate and 2% topical triclosan twice daily for the treatment of Hurley stage I or II hidradenitis suppurativa (HS). At three month baseline, the physicians found that the number of inflammatory nodules per patient, not to mention the median number of new boils, as well as the median erythema score, decreased from baseline (7.3-5, 3-1, and 3-2 respectively). Interestingly, the median modified HS score also reduced from 33 at baseline to 25.5 at three months. They reported that 74% of participants completed a DLQI questionnaire at the 3-month follow-up, revealing the material improvement of the median DLQI score (12.5-8). When consuming a regimen of zinc gluconate, the most common adverse effects included stomach pain and nausea. The triclosan was well tolerated. The team found that the combination of zinc gluconate and triclosan revealed modest but significant improvements for those with mild to moderate hidradenitis suppurativa. Lead investigators included Falk G. Bechara, MD.

A Mayo Clinic Prospective Study

Mayo Clinic researchers conducted a prospective study that reported favorable results for monotherapy with zinc gluconate 90 mg once daily for patients with mild to moderate HS: 36% experienced complete remission, and according to the results 63.6% experienced partial reduction. The study authors estimated that doses of 75 to 118 mg consumed once daily would be recommended to maintain disease dormancy in mild to moderate cases. 14% of the cases reported adverse effects of diarrhea, nausea and stomach problems, and some esophagitis. Authors included Carina M. Woodruff, MD; Abbas M. Charlie, BS, MPH, and Kieron S. Leslie, MBBS, FRCP.

HS Community Feedback

TrialSIte News has a sizeable HS patient following as we are committed to finding ways to make HS easier to live with. For some of our reports, we have had several thousand read them. One of our community members reported seeing a considerable reduction in HS symptoms by taking zinc gluconate. This individual learned of this regimen at the following forum: https://patient.info/forums/discuss/hidradenitis-hs-and-zinc-635417 They said that “over the counter Zinc gluconate could cure you.” This one HS patient awaited one year before posting their results. In a piece of community-driven research, she had her husband randomly switch zinc for another placebo to mock a “blind” study. This individual was convinced of the potential of this approach. When zinc was removed, she went out of remission.

Another HS patient, a high-level corporate executive, reported that they started taking 400 mg of zinc gluconate daily for two weeks. He stated his Hurley stage 3 HS has been clearing up! He says the sinus tracts are healing, and open lesions are closing. He thus far is amazed at the results.

Call to Action: We recommend that HS patients study the use of zinc gluconate. Review some of the studies we have sent. Check-in with your physician and get their opinion—they may or may not agree, but thus far, we see potential. Of course, we cannot give out any medical device as a digital media. We can only report on what we are uncovering.

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