Argentinian Preclinical Animal Research Reveals Potential Ivermectin-based Nasal Spray Targeting SARS-CoV-2

Oct 28, 2020 | Animal Research, Argentina, COVID-19, Ivermectin, Nasal Spray, News, Popular Posts, Preclinical

Argentinian Preclinical Animal Research Reveals Potential Ivermectin-based Nasal Spray Targeting SARS-CoV-2

Multiple research centers, including universities and Laboratorio Elea Phoenix (Elea Laboratories) from Argentina, recently concluded preclinical animal research investigating the safety and pharmacokinetic attributes of an experimental, novel nasal spray-based product developed to inhibit and suppress SARS-CoV-2, the virus behind COVID-19. This investigational nasal formulation was administered in an animal model (pig) and involves the use of Ivermectin, the macrocyclic lactone-based medication that evidences antiviral effects against several distinct positive-single-sense-strand RNA viruses, including SARS-CoV-2. More specifically, the Argentinian preclinical researchers developed a high-concentration nasal formulated investigational product for administration in a primary location for concentrated SARS-CoV-2 penetration and replication—the nasopharyngeal tissue. These animal studies revealed that the experimental formula and delivery method was not only well tolerated but also safe with no adverse events identified. This research represents a preclinical effort; and for experimental use in humans in that nation, the researchers would need to file for an equivalent investigational new drug application. In Argentina, new clinical trials are regulated by the National Administration of Food, Drugs and Medical Devices and known as ANMAT

The researchers, including Jorge Errecalde, were recently on record declaring, “To the best of our knowledge, this is the first time that a nasal IVM (ivermectin) spray formulation is developed and its safety and pharmacokinetic performance determined in a pig model, the most appropriate animal model to use in translational research into humans.” Officially titled, “Ivermectin Repurposing for COVID-19 therapy: Safety and Pharmacokinetic Assessment of a Noel Nasal Spray Formulation in a Pig Model,” the piece was authored by Errecalde J, et al. and uploaded to the preprint server bioRxiv

The research team observed that although this Ivermectin-based nasal formulation shows great promise as a future potential treatment for COVID-19, “In the same direction, further research is also needed to evaluate the potential advantages of a combined nasal plus oral treatment regimen to further contribute to IVM repurposing in COVID-19 therapy.”

A concise summary of the paper was authored by Sally Robertson BSc in News Medical Life Sciences

The Research Centers

Research institutions include Elea Laboratories who have been profiled by TrialSite for other Ivermectin-based COVID-19 research. Back in May, Elea Laboratories launched a proof of concept trial investigating the use of Ivermectin in hospitalized patients. Although that study was supposed to conclude end of September, no updates have been posted as of yet.

Based in Buenos Aires, Elea Laboratories is a biotechnology company that both invests in ongoing and internal research and development operation while also specializing in partnering with international biopharmaceutical companies to in-license promising products for development and commercialization in South America.

Other research institutions represented in this preclinical study included National University of La Plata (Universidad Nacional de Plata)Universidad Nacional del Centro de la Provinca de Buenos AireseBiogensis Bago SRL, and Enfermedades Tropicales Universidad Nacional de Salta

Lead Research/Investigator

Dr. Jorge Errecalde, National University of La Plata

Source: BioRxiv

6 Comments

  1. Enrique Lucchesi

    Fortunately Dr Errecalde and Dr Lanuse are serious in their works. We look forward for next results. Could be good if on April 2020 when internationally following of treatments, just in the world the different therapies implemented by each Country could be comparable by a uniform protocol instead of the huge dispersion of clinical info and confronting therapies.

  2. jim goodyear

    More proof Ivermectin is useful against Covid. According to Dr Thomas Borody of Australia. Effectiveness can be enhanced with Doxycycline, Zinc, Vitamins D3 and B.

    Professor Thomas Borody MB, BS, BSc(Med), MD, PhD, DSc, FRACP, FACP, FACG, AGAF, FRS(N) said:
    “The three medications are on chemist shelves right now. GPs can email GP@CDD.com.au to obtain the dosing protocol and COVID-19 treatment information for their patients.

  3. MR PETER F BELL

    Presumably Nasal spray was thought of when all the critics of ivermectin attempted to extrapolate that too much ivermectin dosage would be needed if it stopped Covid-19 in a petri-dish (in vitro)… they were wrong, but still they push that barrow.
    Now that Dr. Paul Marik has joined Dr. Borody in showing up the critics maybe we’ll get some action but I don’t believe a nasal spray will get off the ground…
    Anyway, with over four billion doses of ivermectin already used for other things, why would you want to test it at all… just use it.
    Testing (RCT-ing) ivermectin would be like testing water for thirst quenching efficacy … not really neccessary.

  4. Anand Veluswamy

    Am writing this from India and we are involved in Covid management.

    Our state guide lines for Covid prevention
    ivermectin is 12 mg on day 1, 7 and 28.

    If positive Covid
    Ivermectin 12 mg twice a day for 5 days.

    Apart from this other drugs we use in prevention
    Vit C, D with zinc and Curcumine.

    For positive cases we add Flavipiravir or hydroxy chloroquine with Asprin.

  5. Anand Veluswamy

    Our medical personnel are using saline plus povidone iodine diluted as nasal, nasopharyngeal wash after work

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