Argentina Study Supports Ivermectin for COVID-19

Sep 26, 2020 | Argentina, COVID-19, Ivermectin, News, Popular Posts, Positive Results

Argentina Study Supports Ivermectin for COVID-19

Argentina’s largest newspaper, Clarin, reported on September 23 about positive results in an ivermectin study, including reduced viral loads, in a study conducted in that nation. Clarin posits that this, “is the first scientific evidence available in the world, which manages to verify the effect of this drug on the coronavirus under in vivo conditions in infected patients.” The results were reported Wednesday from the Ministry of Science and Technology, and followed a four-month effort; the work was conducted by a public-private consortium being led by Alejandro Krolewiecki of the Tropical Diseases Research Institute. Scientists explained that the 0.6 mg/kg dose was three times the amount “usually used.” They said this dose, “produces the fastest and most profound elimination of the virus when treatment is started in the early stages of infection (up to 5 days from the onset of symptoms).”

Awaited Verification Arrives

Studies started in May, after the consortium was chosen for funding. About 6 million pesos was awarded. Testing was done with 45 patients with moderate or mild COVID-19. 30 got the high-dose ivermectin, and the remainder were controls. “Those who received the drug presented an antiviral response significantly different from those not treated, the effect was evidenced in the deeper decrease of virus in secretions”, Krolewieky explicated. He went on, “the most relevant thing is that it is the first study that demonstrates the effect of ivermectin in patients. All over the world a verification was being awaited to establish whether this drug has the potential to treat coronavirus patients.” Experts note that this is a first step, and that we, “will have to carry out other investigations to establish methods of clinical application and the eventual possibility of being used as a prevention tool.”

High Dose, Rapid Virus Elimination

Adrián Lifchitz, professor of Pharmacology at Unicen, was the lead for the study of ivermectin concentrations in plasma samples of the trial subjects. “We found that the medication produced a rapid viral elimination from the body and this helps to reduce the probability of infection. The effect that ivermectin causes on the rate of disappearance of the virus depends on the amount of the drug that is absorbed (amount that enters the organism), after taking it orally. This becomes a proof of concept of high scientific value: it confirms the need to use dose levels higher than those traditionally applied,” according to the Conicet researcher and member of Civetan.

The design, development, and analysis of this study was a public-private cooperation formed by the Veterinary Research Center of Tandil (CIVETAN), UNCPBA-CICPBA-CONICET; the Biotechnological Services Platform-COMTra-National University of Quilmes; the EleaPhoenix SA Laboratory (co-financed the project); the Tropical Diseases Research Institute – National University of Salta – CONICET and the Virology Laboratory of the Garrahan Hospital.

TrialSite notes that article quotations relied on Google Translate.

Source: Clarin

15 Comments

  1. German Villamizar

    Thank you!!!

  2. MR PETER F BELL

    Why did this study not include the accepted dose rate for large adults of 12 mg (approx .200/kg bodyweight) ?
    The trialsite news a few days ago shows Bangladesh peer-reviewed trial as being a much better than this ham-fisted effort.

    • Eric

      Trial was done with .6 mg/kg.
      It is three times accepted dose of 12mg for large adults, higher that accepted but still safe to administer.
      “Lo que buscamos es en la etapa temprana una herramienta para bajar la carga viral y que le de sustento a la respuesta inmune del individuo para que se pueda defender”
      What this reasearch was looking for in the early stage of the disease is a way to lower the viral load and that supports the individual’s immune response so that it can defend itself.

  3. Arshad Hossain

    Ivermectin is already being useed in Bangladesh for long time with positive results.

  4. Name *Jose David Legatda Cruz

    Es increible omo han presionado desde la OMS para frenar el uso de la ivermectina.

  5. Bob Baker

    We have seen this used aggressively safely effectively and even as a prophylactic in countries like india. Given ivermectins low cost and low risk, lack of wide use tells us with certainty that the power grabbing and corruot politicians of the world have executed a hoax against their citizens requiring them to wait for endless testing endless controversy about such worthwhile treatments while all the while punishing them with quarantine loss of job loss of income and unnecessary loss of life god damn the corrupt politicians

  6. Jeff

    These clinical investigations are great when people are not dropping like flies or get damaged waiting for these clinical trials to continue….There are so many observational studies made by now by so many doctors, and show the drug does no harm taking it within amounts given in its safe rages…If everyone had this drug in their medicine at the first onset of any symptoms it would be a lifesaver for so many…It appears in every case, without exception ,will definitely lower the viral load within the body within hours and allow the body to better defend it self so there is a much lower over immunological reaction by the body which starts to accelerating within 7 days. .This has been observed for months now…Residends in a nursing home in Canada, who averaged 80 years old were completely protected when taking this drug for a scabies outbreak…While covid 19 was being caught by nurses who werent taken Ivermectin, all of thiose 80 and up residents were all fine…The sad part is ,try to get some for yourself without parasites leaping from your head …Its very difficult….I tried…A dog can get that from the Vet then we can can get it !!!!

    • Dennis Ray Abrameit

      The scabies in the nursing home and covid being stopped in the same people was something I had wondered about and I hope Merk and the FDA hear about it

    • Randal

      In the US or Canada you can order Ivermectin online from India with a visa card and no prescription.
      This is a safe pharmacy That I use.

      • arpit shah

        Which pharmacy? Website?

        • KAren Suarez

          I saw, on another thread, someone used Baxton Pharmacia. I checked their website – appears you have to furnish your telephone number and talk with someone first? The person who ordered from this pharmacy did not give details but did say he ordered Varoxy-400 (HCQ).

  7. Robert Wall

    What we know about good treatment results with Ivermectin is almost exclusively a result of the excellent reporting of Trial Site news and they should be commended.

    If we depended on the mainstream media and USA governments reports we would know the FDA has already warned USA residents not to use Ivermectin to treat Covid-19; and not to use Hydroxychlorquine based treatments to treat Covid-19 because of a possible QT interval problem that may lead to many deaths despite the fact that the FDA has not produced any credible supporting data according to Yale Epidemiologist Dr. Harvey Risch; who has pressed the FDA in vain to provide such data, particularly for early treated patients using non-toxic doses of HCQ.

    Ivermectin treatments have shown good results in the Dominican Republic at a initial dose of 400 micrograms/kg in a 1300 patient study as reported by TrialSite News, who quoted Dr. Jose Redondo. There is evidence that Dr Redondo also stated they recommend a wash out dose of Ivermectin at 200ug /kg at 7 days after the loading dose.

    Trial Site News also first reported good Ivermectin treatment results in a 100 patient Bangladesh study that used 200 micrograms/kg.

    Regarding the Argentina study that used 600 ug/kg single dose of Ivermectin, perhaps TrialSite could find out the doses of any antibiotic used and for how long and the zinc dose if any and the type of zinc used as well as Vit C and D if any. Also how did they measure the reduction in the viral load.

    • Dennis Ray Abrameit

      I’ve seen writings on the internet and a video about low D3 being a normal for Corona patients. I hope someone is checking that out too. But I’m taking 400 iu just for fun. It’s a low dose because vitamin D3 builds up in your body like iron and zinc they can be bad if you take too much

  8. George Hody, MD

    This seems very promising and encouraging but it is a small study and this report is not technical and does not include original data. If anyone knows where, if anywhere, this has been published or is planned to be published, preferably with peer review, I would very much appreciate it if you would post the information about it here. I would also be especially grateful if you could email a link or journal reference to me at glhody@gmail.com. Thank you. G. L. Hody, MD San Diego, CA, USA

  9. ROBERT WALL

    SUMMARY OF SOME IMPORTANT FACTS ABOUT IVERMECTIN

    Another name for Ivermectin is Stromectol. This link below is a data sheet established by Merk.com. This link discusses many properties of Ivermectin, including typical doses used, maximum doses tested, and how Ivermectin behaves in the human body and much more.

    https://www.merck.com/product/usa/pi_circulars/s/stromectol/stromectol_pi.pdf

    Below are some important quotes taken from the data in the link above:

    CLINICAL PHARMACOLOGY -Pharmacokinetics

    Following oral administration of Ivermectin, plasma concentrations are approximately proportional to the dose.

    Ivermectin is metabolized in the liver, and Ivermectin and/or its metabolites are excreted almost exclusively in the feces over an estimated 12 days, with less than 1% of the administered dose excreted in the urine. The plasma half-life of Ivermectin in man is approximately 18 hours following oral administration.

    The safety and pharmacokinetic properties of Ivermectin were further assessed in a multiple-dose clinical pharmacokinetic study involving 109 healthy volunteers. Subjects received oral doses of 30 to 120 mg (333 to 2000 mcg/kg) Ivermectin in a fasted state or 30 mg (333 to 600 mcg/kg) Ivermectin following a standard high-fat (48.6 g of fat) meal. (Robert Wall Comment: Ivermectin concentrations up of 2,000 micrograms/ kg which have been tested in humans are more than 3 times the dose (600 mcg/kg) used in the Argentina study. Hence the 600 mcg/kg dose may be a safe dose to treat sick Covid-19 victims, but more testing is definitely needed)

    Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5-fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state. (Robert Wall Comment: The authors of the Argentina Study which used Ivermectin dose of 600 micrograms/kg seems to suggest the amount of Ivermectin that is obtained in the patients blood plasma is proportional to the effectiveness of Ivermectin in treating Covid-19 patients; hence does this data suggest new Covid-19 victims should eat a high fat meal before taking Ivermectin?

    STROMECTOL should be taken on an empty stomach with water. (Robert Wall comment: which is better, to take Ivermectin on an empty stomach or take it after eating a high fat meal? Maybe the Argentina authors or others will answer this question. )

    Ivermectin does not readily cross the blood-brain barrier in humans.

    STROMECTOL is excreted in human milk in low concentrations.

    In four clinical studies involving a total of 109 patients given either one or two doses of 170 to 200 mcg/kg of STROMECTOL (IVERMECTIN) , the following adverse reactions were reported as possibly, probably, or definitely related to STROMECTOL: Body as a Whole: asthenia/fatigue (0.9%), abdominal pain (0.9%) Gastrointestinal: anorexia (0.9%), constipation (0.9%), diarrhea (1.8%), nausea (1.8%), vomiting (0.9%) Nervous System/Psychiatric: dizziness (2.8%), somnolence (0.9%), vertigo (0.9%), tremor (0.9%)Skin: pruritus (2.8%), rash (0.9%), and urticaria (0.9%).

    Robert Wall Comment: On the average only 1 patient out of 109 had fatigue, abdominal pain, gastrointestinal-anorexia, constipation, vertigo, vomiting, somnolence, tremor, rash and urticaria. Two patients had nausea and diarrhea, 3 were dizzy and had pruritus. Hence, we must conclude the large majority of the 109 patients treated with Ivermectin had few adverse side effects.

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