Researchers, led by Ann & Robert H. Lurie Children’s Hospital of Chicago, studied a non-invasive tape strip treatment in young children with eczema (atopic dermatitis) found many molecular signs of immune dysfunction and skin changes that relate to disease activity. The biomarkers were present prior to the eczema becoming visible and hence can be used to track disease activity over time. These biomarkers may help predict response to medicine and development of conditions associated with eczema, such as asthma, and other allergies, infections and even attention deficit disorder (ADHD).
The findings were recently reported in JAMA Dermatology.
A long-lasting, inflammatory, extremely itchy skin disorder impacting 10-20% of children in the United States—a surprisingly large number. Currently, molecular profiling of skin biopsies is the gold standard for evaluating atopic dermatitis.
With 51 participants under 5—21 of the participants had moderate to severe atopic dermatitis that had its onset less than six months previously. Tape strips were collected from the skin with and without lesions in the children who had atopic dermatitis, as well as from the normal skin of children who did not have the condition. Researchers evaluated gene expression of 77 biomarkers of immune dysfunction and skin barrier changes (97% of biomarkers assessed) in children with atopic dermatitis.
The Research Site
Research at Ann & Robert H. Lurie Children’s Hospital of Chicago is conducted through the Stanley Manne Children’s Research Institute. The Manne Research Institute is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge. Lurie Children’s is ranked as one of the nation’s top children’s hospitals by U.S. News & World Report. It is the pediatric training ground for Northwestern University Feinberg School of Medicine. Last year, the hospital served more than 220,000 children from 48 states and 49 countries.
Amy Paller, noted “In young children, skin biopsies are virtiaully impossible to perform, even in research, since they are painful and leave scars.” She continued, saying that “This reinforced our desire to find a way to evaluate these kids that did not hurt at all.”
Call to Action: Interested in learning more? TrialSite News can delve deeper into this strip treatment if there are requests.Source: Ann & Robert H. Lurie Children’s Hospital of Chicago