Tetralogy of Fallot  is a combination of four congenital heart defects which cause oxygen-poor blood to flow out of the heart and to the rest of the body, often resulting in a blueish tinge to skin and difficulty in breathing.  Generally, surgery is required prior to 6 months of age, followed by additional treatments that can enlarge the left ventricle of the heart and possibly lead to heart failure.

Tetralogy of Fallot affects some 85,000 people in the U.S., making up 20% of congenital heart disease.

Dr. Andrew McColloch and Dr. Jeff Omens of UCSD are two of the principal researchers of the Cardiac Atlas Project, awarded the $3.1 million grant by the National Heart Lung and Blood Institute, a part of the National Institutes of Health.  The goal  of the Congenital Heart Disease (CHD) Atlas, part of the Cardiac Atlas Project is to create a database of cardiac images and computational models in CHD patients and compare them statistically against a database of other, similar CHD patient examinations in order to provide optimal management of CHD and better treatment options. 

The 2019 Nature Index ranked University of California San Diego ninth among the top 200 institutions in biomedical sciences worldwide.

Leading the project are: Andrew D. McCulloch, Ph.D. and Jeff Omens, Ph.D. at UC San Diego;  Dr. Sanjeet Hegde and Dr. James Perry of Rady Children’s Hospital in San Diego, as well as Dr. Kathleen Gilbert  and Dr. Alistair Young of The University of Auckland, NZ

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