Washington University ‘DIAN’ Alzheimer’s Clinical Trial Adopts BYOD

Jun 18, 2019 | BYOD, Clinical Technology, Digital Health

Contemporary gadgets for medical employee

The DIAN study stands for Dominantly Inherited Alzheimer Network Observation Study and it enables researchers around the world to monitor and identify changes in individuals who carry one of the gene mutations (Presenilin1, Presenilin2 or APP) known to cause dominantly inherited Alzheimer’s disease (DIAD). There is currently no treatment that can prevent or delay the progression of AD, and no new treatments have been approved in over 10 years. DIAN aims to define the natural history of AD and establish reliable biomarkers that track with the disease.

Datacubed Health’s mobile platform has been selected by Washington University School of Medicine, St. Louis, to support the DIAN study. The app and portal and gamified experience with rewards for completion and compliance. Participants navigate an interactive map journey creating variable rewards such as digital gems and visual progress as they complete articles, surveys and tasks.

Datacubed Health’s tools enable researchers and study coordinators to enroll participants, monitor real-time progress and compliance dashboards, manage incentives and review study data.

The Linkt app and portal will also be used to support a registry for families confirmed or suspected to have the disease and a longitudinal observational study of family members with parents who have the gene mutation associated with the disease. With research suggesting that brain changes occur years before symptoms develop, the goal is to identify these changes in presymptomatic carriers. Ultimately researchers hope to develop therapies to detect and treat DIAD at its earliest stages—or prevent it altogether.

Principal Investigator for the DIAN study Eric McDade noted “The DIAN study represents one of the most important opportunities to understand Alzheimer’s disease” and “ We are excited to partner with Datacubed Health in order to bring a new set of tools to interact with our participants and collect information outside of the typical research environment.”

Lead Research/Investigator

Eric McDade

Who is Datacubed Health?

Datacubed Health is a pioneering technology company making better science and healthier communities a reality. We apply individualized solutions for the capture of data, including smartphone apps, wearable, in-home, and environmental sensors. We specialize in remote engagement with patients and virtual clinical studies. Focusing on healthcare and life sciences, Datacubed Health offers software and services based on behavioral science to improve patient retention and compliance, resulting in better data and positive health outcomes. We believe that the best way to unlock the insights that have eluded scientists in understanding the holistic life of an individual.


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