Krembil Research Institute, University Health Network, Toronto has led a stem cell-based clinical trial evidencing considerable promise for safe, effective relief from arthritic knees. In the case of this trial, stem cells were collected from the patient’s own bone marrow as they represent great promise for a potential therapy for osteoarthritis of the knee (KOA). They have the ability to regenerate the damaged cartilage. Recent results of this study were published in STEM CELLS Translational Medicine (SCTM).
With 12 participating patients aged 45 to 65 with moderate to severe KOA, the patients were divided into three groups each receiving a different dose of MSCs Researchers tracked these patients for the next year using imaging, biomarkers, molecular fingerprinting and the patient’s own assessment of health, pain levels, etc.
At the end of the year period, patient pain levels and quality of life were on the measurable upswing. Moreover this study evidence that MSCs were safe at the levels and doses tested and that effectivity was correlated with dose level.
Sowmya Viswanathan, PhD