The National Institutes of Health have selected MCG and 6 other centers nationwide to participate in its “first-ever multi-center randomized pre-clinical trial to identify the most promising methods for protecting and preserving the brain before and after a stroke.”
The additional centers/labs included are: Cedars Sinai Medical Center/University of California Los Angeles; McGovern Medical School at UTHealth in Houston; Massachusetts General Hospital in Boston; Johns Hopkins University in Baltimore; the University of Iowa in Iowa City; and the Yale School of Medicine in New Haven, Conn.
These seven labs nationwide will be testing the proposed therapies of another lab and a third lab will perform the necessary data analysis. This method of research is designed to “really get rid of that bias that has been inherent in research,” according to Dr. Krishnan Dhandapani, a neurosurgery professor and stroke researcher who will be leading MCG’s part. In addition, the labs won’t know what agents they are testing to limit bias, and no lab will be testing its own agent.
As reported in the Augusta Chronicle, “MCG’s candidate is called remote ischemic conditioning, but it is as simple as inflating a blood pressure cuff for five minutes and then deflating it for five minutes for four cycles.” Other proposed brain preservation techniques include antioxidants, drugs that affect the immune system or impact cell death or impact the cardiovascular system.
The goal is to have one consensus as to which therapy is the most promising candidate.
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