During a ‘Hackathon,’ researchers from Harvard Medical School along with the Novartis Institutes for BioMedical Research developed a compelling tool that predicts how drug candidates may trigger adverse reactions before they actually reach human clinical trials or...
Harvard
Category
Disulfiram: Could this be Repurposed to Target An Over-Active Immune System Associated with the COVID-19 Cytokine Storm?
Researchers from Harvard Medical School and Boston Children’s Hospital reveal that the FDA-approved drug disulfiram, often used to treat alcoholism, blocks a key gatekeeper protein contributing to inflammation. COVID-19 kills not because of the virus itself, but...
What makes SARS-CoV-2, the virus behind COVID-19, such a threat?
A new study in Cell led by researchers at Harvard Medical School, Boston Children's Hospital and MIT pinpoints the likely cell types the virus infects. The study also unexpectedly showed that one of the body’s main defenses against viral infections may actually help...
Wyss Institute & Tel Aviv University Researchers Create Mini Human-on-a-Chip Technology to Accelerate Drug Trials
Tel Aviv and Harvard University researchers developed mini-human organs-on-a-chip in pursuit of drug development acceleration. Sounding like some sort of science fiction-based activity, the researchers were able to connect nine organs via these mini chips including a...
FDA Approves More Drugs & Faster but Are Drugs Better and Patients Safer? A Harvard Study Questions
The Food and Drug Administration’s (FDA) attempts at expediting and streamlining the approval of advanced new medicines is surely appreciated by those in the public that understand the importance of access to such therapies to address serious disease. And in fact,...
William G. Kaelin, Jr. MD Dana-Farber Cancer Institute and 2019 Nobel Prize Winner & Live Saver
William G. Kaelin, Jr. MD won the 2019 Nobel Prize in medicine. His research findings at Dana-Farber are game-changing: a rare disorder called von Hippel Lindau syndrome, triggered when one tumor-suppressor gene called VHL mutates, makes patients more likely to...
New Harvard Medical School Led, DOD-Financed Consortium to Develop Alternative Pain Therapies to Opioids
A new consortium, based at the Laboratory of Systems Pharmacology (LSP) at Harvard Medical School, has launched an ambitious project titled STOP PAIN (Safe Therapeutic Options for Pain and Inflammation). By combining a wide range of experimental and artificial...
Major Grant for Study of Cell Fate in Cancer
Harvard Medical School researcher Peter Kharchenko and three collaborators have won a six-year multimillion-dollar grant from the European Research Council for their work toward mapping out cellular decision-making during early development in an effort to illuminate...
Moderna & Harvard Inc. Strategic Preclinical Research Pact Focusing on Immunological Diseases
Moderna Inc. is a clinical-stage biotech venture pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines announced a multi-year research collaboration and associated investment with Harvard University with the...
Harvard Breakthrough Anti-Cancer Agent E7130 Nearing Clinicals
Harvard University chemists have achieved a “landmark in drug discovery” with the synthesis of halichondrin, known to be a potent anti-cancer agent in preclinical mouse studies. Naturally found in sea sponges in tiny quantities, the halichondrin class of molecule is...
Harvard Research: Reduce Cardiovascular Disease by Replacing Red Meat with Plant Protein
Harvard T.H. Chan School of Public Health has conducted a comprehensive meta-analysis of trials comparing the health effects of red meat consumption with those of other diets found that substituting healthful plant protein for red meat helps lower the risk of...
Harvard & Rand Corp Study Evidence: Massive Opioid Prescriptions Clinical Need Absent
Nearly 30 percent of outpatient opioid prescriptions in the United States lack documented clinical reasons that justify the use of these potent drugs, according to a national analysis of physician visit records conducted by researchers at Harvard Medical School and...