Cytokine Storm

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Stakes Get Bigger as Patient Health and Success of Humanigen Platform Depend on Evidence from COVID-19 Clinical Trials

San Francisco Bay Area biotech venture Humanigen, Inc. (HGEN), formerly known as KaloBios Pharmaceuticals, is a clinical stage company focused on preventing and treating cytokine storm with lenzilumab, their proprietary Humaneered® anti-human granulocyte...

Landmark Hospitals Compassionate Use Study for Critical COVID-19 Patients Evidences Potential for Allogenic Biologic Product

Landmark Hospital manages six long-term acute care hospitals across the Southeast United States and recently announced its decision to offer an investigational allogenic biologic product derived from amniotic fluid to patients with advanced COVID-19 conditions under...

Cincinnati Children’s Investigator Idea May Lead to Answer to COVID-19 Deadly Cytokine Storm: Ruxolitinib

Cincinnati Children’s researchers initially developed a transgenic mouse to model HLH (hemophagocytic lymphohistiocytosis), a deadly childhood immune disease but as it now turns out this effort may end up saving lives during the COVID-19 pandemic. Cincinnati...

HHMI-backed Johns Hopkins Hosted Team Investigates Use of Alpha Blockers (Prazosin) to Combat a Deadly COVID-19 Condition: Cytokine Storm

Although considered eccentric toward the end, Howard Hughes was incredibly rich and put that capital to work in many interesting and important ways, including what has become one of the largest private funding organizations for biological medical research in the...

B.C. Research Focuses on Managing Immune Response in Critically ill COVID-19 Patients

British Columbia (B.C.) physicians and scientists are learning more about the links between the body’s immune system and the new coronavirus after the recovery of a 32-year-old who nearly died from acute COVID-19. Physicians and researchers at Vancouver General...

Disulfiram: Could this be Repurposed to Target An Over-Active Immune System Associated with the COVID-19 Cytokine Storm?

Researchers from Harvard Medical School and Boston Children’s Hospital reveal that the FDA-approved drug disulfiram, often used to treat alcoholism, blocks a key gatekeeper protein contributing to inflammation. COVID-19 kills not because of the virus itself, but...

Retrospective Study of COVID-19 ARDS Patients Led by San Raffaele University Points to Sobi’s Anakinra Promise: Clinical Trials Required

Researchers from Vita-Salute San Raffaele University as well as collaborative colleagues recently concluded a small retrospective study based in Italy focusing on the most at risk of COVID-19 patients. The mortality rates for those SARS-CoV-2 patients afflicted with...

USC Keck Medicine Launches Clinical Trial to Study Baricitinib, an Anti-Inflammatory, as COVID-19 Treatment for Severe Cases

Keck Medicine of USC physicians are launching a clinical trial to evaluate the efficacy and safety of baricitinib, an anti-inflammatory drug approved by the Food and Drug Administration to treat rheumatoid arthritis, as a possible treatment for patients with moderate...

Virginia Commonwealth Commences Canakinumab Study Targeting Severe COVID-19 Patients with Pneumonia

Virginia Commonwealth University (VCU), a prominent public research university in Richmond, Virginia, became one of the first clinical investigational sites in the world to begin clinical trials to study the safety and efficacy of the Novartis drug canakinumab on...

Patient’s Life Saved by Small Trial led by Hudson Health’s Dr. Tom Pitts’ Investigation into Eculizumab for Severe COVID-19 Cases

Amy De Vos was fighting for her life. The 45-year-old out of a small town called Troy, Ohio (near Dayton) was in critical condition—spending 29 days in Upper Valley Medical Center with COVID-19. As her conditioned worsened in the hospital, her doctor, Dr. Eleina...

Yale to Launch Clinical Trial for Severe COVID-19 Patients with Ibudilast—an Asthma Medication from Japan

Clinical investigators at Yale-New Haven Hospital are investigating the efficacy of ibudilast (MN-166) for treating acute respiratory distress syndrome (ARDS), the life-threatening condition developed by some of the most severe cases seen in COVID-19 patients. These...

The FDA Approving Experimental Stem Cell Therapies Targeting Patients with Severe COVID-19 Cases

Novel medical innovations are being pursued by biotech companies and clinical investigators to halt COVID-19 causalities as there is, presently, no approved treatment for the novel coronavirus—especially in severe, escalated conditions where mortality is more...

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